Regardless of any health benefits from nicotine, it is still a vasoconstrictor, which is bad news for the circulatory system. I would think that the best "healthy" result from
vaping would come from very low level nic liquids, lower than most vapers are using. Nic is present in a number of veggies, but in very low levels compared to tobacco or ejuice.
PG might have a germicidal effect that could be beneficial. Nicotine may have a positive impact on ulcerative colitis, and/or alzheimers, and/or parkinsons.
vaping may eliminate 99.7%+ of the carcinogens in smoking, as well as the soot and other chemicals, which means a virtual elimination of pulminary disease and cancer compared with smoking.
But, as long as nic levels remain relatively high, vaping does little to combat the risk of heart attack and stroke associated with smoking.
IMO, healthiest vaping would also probably mean: sans flavors, sweeteners, and additives that increase TH. Nothing but PG (if you aren't allergic) and a
small amount of nicotine. That would also be fairly boring vaping for most.
I know that smoking effects the downstairs piping as well, but I don't know how much of that is due to the effects of soot and CO in cigarettes or the vasoconstrictor effect of nicotine. I could be wrong, but I would suspect that men would do well if they could lower or eliminate their their nicotine consumption.