True story. When I first started vaping, Caramel Tobacco by Bluemist Vaping was my holy grail juice. I think I was somewhere around 12mg. When I worked my way down to 3mg I reordered my coveted 120ml bottle of Caramel Tobacco. Not only was it a totally different color (at 12mg it was a lovely caramel brown. At 3mg it was a yellowish clear and it tasted nothing like my holy grail juice. Don't get me wrong, this was not a bad juice overall, so it wasn't a quality issue. It was simply that I had become accustomed to a particular flavor and at a fraction of the nicotine level I had been vaping before it was highly discernible.
But, like most things, you do get used to the change.