Electronic nicotine delivery systems: a research agenda - JF Etter et al

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rolygate

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A new paper on e-cigarettes published in the BMJ today by JF Etter and colleagues:

Electronic nicotine delivery systems: a research agenda -- Etter et al. -- Tobacco Control

The full PDF is available by subscription only. The paper is published in the tobacco Control section of the BMJ: Tobacco Control - BMJ Journals

The paper's authors are a who's-who of medical professionals interested in the e-cigarette: Jean-François Etter, Chris Bullen, Andreas D Flouris, Murray Laugesen, Thomas Eissenberg.

The abstract states, I think, that we don't know much about e-cigarettes and research is needed to establish the health impact, if any; and whether e-cigarettes can be used for smoking cessation. Regulation is needed but a hotchpotch of rules have or have not been applied, so far.

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The most significant aspect is that several well-known, widely dispersed researchers who have worked with or commented on e-cigarettes, are involved.

It would be hard to disagree with the opinions expressed in the abstract. Some sort of regulation is needed - but the argument will generally be over exactly what kind. The fact is that consumer product regulations and oversight, especially in the area of foods and products consumed, is in a chaotic state even in many countries where things should be better organized (such as the US and UK for example).

The Royal College of Physicians in the UK appealed for a tobacco products oversight board to be set up, and that seems a reasonable request.

The problem is threefold:
1. Buyers of consumer products do not want a medical licensing authority regulating their products because that is a ridiculous situation in the first place, and essentially means 99.9% of products will be removed from the market.[1]
2. Consumer products are spectacularly poorly regulated considering the funding available, the importance of the issues, and the potential effects on the public.[2]
3. There is a fundamental difference of opinion among users, medics and commentators about what an e-cigarette is for in the first place.[3]

[1] It's hard to see why products like low-alcohol beer or low-nicotine tobacco (or whatever) could be described as medicines or require licensing as pharmaceuticals; but this is the issue we face with e-cigarettes, which are simply a substitute for tobacco cigarettes.

[2] For example: the UK at least has a functional Trading Standards system that operates at hyper-local level, but describing it as 'comprehensive, efficient, well-managed' would be slightly optimistic. Its overall management, above all, is poor - local staff work efficiently considering the system is effectively headless (it has little importance at government level and needs a total restructure).

[3] The majority of e-cigarette users do not intend to quit smoking. They are looking for a better alternative, and have switched to a substitute that has no smoke and is therefore likely to have less health impact. It is up to researchers to decide exactly what the implications are - but it is not up to researchers to tell users what they are or are not doing. Some might want to quit, some might want to reduce the nicotine level, some might want to just keep on as they are - and the latter group appears to be the largest by far. Above all, e-cigarette users are not using some sort of medicinal product or participating in some kind of therapy - any more than someone who drinks low-alcohol beer is.

There may be a slight conflict of interest here in the work of some of the researchers, since (a) they are medics and thus regard everything as a medical process, and (b) some may be committed members of the Tobacco Control movement, which seems more associated with 'quit smoking' than alternative solutions. There are less hazardous smoking alternatives, and consumers above all do not want more 'control' that gives them less options.

Harm Reduction as a consumer-driven process needs more emphasis and less regulatory impediment. No one is saying that there should not be some form of analysis and quality control of consumed materials - but in the end the question is: who will be doing it? Consumers will not accept any form of pharmaceutical agency involved in the process because, firstly, it is not relevant; and, in addition, that system is so obviously corrupt, clearly working to the pharma industry's agenda. The current national consumer protection agencies may or may not be up to the task. Tobacco products oversight as a separate materials regulatory system may or may not be appropriate - depending on its implementation.
 
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rolygate

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Thanks. It seems to me that everyone who is involved has a different agenda - the e-cigarette community's is quite simple: please just leave us alone. (Although if someone wants to provide materials analysis for us with no strings attached, then we wouldn't argue...)

Everyone else's agenda differs in some way. The medics have done a great job up to now, but there remains a nagging doubt about the attraction of regulation to them. Unfortunately, at present there is no sane form of regulatory structure - as I tried to point out. There is a possibility that the medics may see my comments as some form of criticism, but I am certainly not attacking their work; it just seems as if regulation is more attractive to them than it is to us.

There is no good regulation - certainly within today's frameworks. The UK system (Trading Standards) works well enough, but it is inherently so weak due to its management structure that others may find it too ineffectual. Since its central management at LACORS demonstrated their incompetence so comprehensively recently, their reputation is a little shaky.
 
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Thanks for your views here.

And there's the rub....

The point of your top paragraph is all important (post #4, please leave us alone.).
A better way of saying it is "Who do you think you are, to interfere with my choices?" Regulations instituted by agenda driven agencies or even with good purpose is an infringement of my right, and a Nanny State, move which is not just unappreciated but unwarranted.
If what I'm doing does "no harm to others", it's not the government or authorities business. It hasn't been proven 2nd hand vapors re of any harm.
The FDA has been repeatedly found untrustworthy, as has the American Cancer Society, and American Lung Association (hanging on the fda's coat tails here).
It also appears the FDA has been bought off, as have many politicians whose campaign contributions are many times aided by pharma/medical sources, appear (and are) tainted.
And don't get me started on the effectiveness of the ACS, as a cancer survivor (prostate). They have been given $$billions$$ over the decades and are ineffective , to be "very" kind.

In all the research being done and been done, I see little to tell me the e-cig juices are of any degree of harm at or nearing what cigarettes are, and even if found worse (impossible), it is my my choice.

So the fight for personal rights continues in many venues of life here in the USA.

Earthpig
 
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Bill Godshall

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It should be noted that this article was originally submitted for publication more than a year ago (I think before Judge Leon ruled that the FDA didn't have the authority to regulate e-cigarettes as drug devices).

While I welcome any objective research on e-cigarettes, the authors of this article imply (but never actually stated) that e-cigarettes should remain banned until/unless their research agenda takes place. The authors also failed to indicate who should fund their extensive research agenda, which appears to indicate that they believe e-cigarette companies should fund it.
 

teissenb

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Mr. Godshall is incorrect when he states that "this article was originally submitted for publication more than a year ago..." I do not have the exact date of submission, but e-mail records I have in front of me right now make clear that the manuscript was submitted to Tobacco Control after November 11, 2010. So, about 6 months ago and *not* "more than a year ago".

While authors generally welcome comment on published work, even regarding seemingly trivial issues such as manuscript submission dates, I hope we can all agree that factual comments are most useful.

Additionally and perhaps obviously, when authors choose not to state an opinion in a published document, that choice in no way should be construed as having an opinion (e.g., with regard to banning products or research funding). The authors of the article under discussion are a diverse group with many differing opinions across an array of related issues. To state that not writing an opinion somehow indicates an opinion does a disservice to each author individually as well as to the diversity of the group.
 
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