Email - Please Forward

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Vocalek

CASAA Activist
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I have drafted an email that I plan to send to all of my friends and relatives, asking them to forward.

Comments welcome:


Are there people in your life who are tobacco smokers? Have they tried time and again to quit, without success? Do you wish there was some way you could help them stop?

What if there was an invention that would allow many, if not most, of the 45 million American smokers to quit—without any desire to go back to tobacco?

And what if very powerful groups were trying to force this product off the market by inaccurate accusations and deceptive claims about potential harm? Is that ethical? Is that in the best interests of public health?

The invention is known by many names, the most common of which is the “electronic cigarette”. It is a battery-operated mechanism that produces vaporized nicotine. There is no tar, no particulates, no ash, no carbon monoxide, no risk of passive smoking, and no unpleasant odor.

The electronic cigarette is marketed to current smokers, not as a smoking cessation product, but as an alternative to smoking tobacco cigarettes, for occasional use where smoking is not permitted. But many are finding that this is an acceptable substitute for all of their tobacco cigarettes. In one survey on an electronic cigarettes forum, 73% of voters reported that they have completely quit using tobacco cigarettes.

This is an amazing success rate. To date, nearly 13,000 people have signed The Electronic Cigarette Petition: http://www.thepetitionsite.com/1/keep-life-saving-electronic-cigarettes-available. Go to the site. Read the comments. People who smoked for decades and tried over and over to quit have finally been able to stop smoking tobacco, thanks to these products. They are reporting remarkable improvements in their health, many of which have been verified by their doctors.

These products work because they provide adequate levels of nicotine. When people who are dependent reduce or eliminate their intake of nicotine, they become moody, depressed, anxious, and irritable. They start making mistakes no matter how hard they try to concentrate. They have problems remembering things. Given these circumstances, is it any wonder that most people resume smoking within the first two weeks after quitting? How long would most of us be able to get away with moodiness, forgetfulness, and making mistakes on the job? And how do such symptoms affect the performance of every-day tasks such as balancing the checkbook, taking medications, shopping, driving the car, or supervising children?

Many researchers suspect that people who are highly dependent on nicotine are using it to self-treat underlying disorders. Nicotine is being studied as a potential treatment for such conditions as attention deficits, Alzheimer’s, depression, anxiety, pain relief, Tourette Syndrome, inflammatory bowel disease, ulcerative colitis, schizophrenia, and epilepsy, as well as both treatment and prevention of Parkinson’s. Nicotine has none of the serious adverse effects that prescription antidepressants, corticosteroids, anti-seizure, anti-anxiety, and schizophrenia medications can cause.

Nicotine is not a carcinogen. Nicotine is not proven to cause heart attacks and strokes. Nicotine does not cause lung disease. Smoking can cause all of these, and it is the SMOKE--the product of combustion of the tobacco and paper, along with the thousands of additional carcinogens and toxins--that is the culprit.

The smoker you love may not be able to function without adequate levels of nicotine. And yet the attitude of the health organizations, anti-smoking groups, and even the FDA seems to be, “you should just quit or die.”

You may have heard that the FDA announced that it found harmful substances in some of the electronic cigarette cartridges it tested. What you did not hear is that most of these same substances are in their own approved nicotine-replacement products. And what you also did not hear is that all of the substances they found are in tobacco cigarettes in quantities that are orders-of-magnitude higher.

So if you care about the life and the health of someone who smokes, please help.

· Visit the Electronic Cigarette Petition site and add your name to nearly 13,000 others who have signed.

· Write to your elected federal officials, including President Obama, and ask them to take action to keep these life-saving devices available. You can find contact information for government officials here: http://www.usa.gov/Contact/Elected.shtml
· Tell the FDA how you feel about their ethics and their distorted, incomplete, and misleading statement. Tell Commissioner Hamburg that these products need to be kept on the market for the health and safety of those who might go back to tobacco without them. margaret.hamburg@fda.hhs.gov

· If you contribute to the American Lung Association, the American Cancer Society, and/or the American Heart Association, tell them you believe that their “quit or die” approach is heartless and unethical.

· If you support anti-smoking groups, make sure they know that your beef is with tobacco, not with any product that helps people get off and stay off tobacco.

Most importantly, PASS THIS MESSAGE ON. Send it to everyone you know who is a smoker or who cares about someone who smokes.
 
Last edited:

Talen

Senior Member
ECF Veteran
Jun 23, 2009
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East Coast U.S.A/Thailand
Nicotine is not a carcinogen. Nicotine is not proven to cause heart attacks and strokes. Nicotine does not cause lung disease. Smoking can cause all of these, and it is the SMOKE--the product of combustion of the tobacco and paper, along with the thousands of additional carcinogens and toxins--that is the culprit.

Not exactly true. Nicotine has definitely been proven to be an artery hardening agent...hardened arteries lead to blockages and heart attacks. This is scientific fact.
 

vjnnc

Senior Member
ECF Veteran
Jul 7, 2009
73
1
Very well written - excellent, indeed. Now for the criticism - a bit lengthy; most (even friends and family) won't take the time to read all of it.

In the 4th paragraph where most will stop reading (not being harsh - it's reality), I would try to incorporate your 9th paragraph - it's one of the most important benefits of the E-cigarette.

Just my two cents worth.
 

Superstargoddess

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Jul 31, 2009
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Not exactly true. Nicotine has definitely been proven to be an artery hardening agent...hardened arteries lead to blockages and heart attacks. This is scientific fact.

First of all, very nice letter, though it is a bit long and I agree that it should be very much so condensed while still somehow keeping the posterity of the whole thing.

As for Talen- Heck, everything out there can give you hardened arteries, maybe they should ban McDonalds! But I understand what you are saying, when people write these types of things, they really need to be sure of the facts before they post something as a fact.
 

Vocalek

CASAA Activist
Supporting Member
ECF Veteran
To my knowledge, this is the only study done on humans regarding the topic:

"To investigate, the researchers administered 1 milligram of nicotine via a nasal spray or cigarette smoke to 16 healthy long-term smokers, and then used ultrasound to examine the endothelium after 20 minutes. Nicotine-containing nasal spray was less damaging than cigarette smoke but still reduced blood flow inside the artery, the study found.

It is not clear how nicotine damages the endothelium but studies in animals indicate that chronic exposure to the compound leads to oxidative stress, or damage by free radicals. Other compounds in cigarette smoke may contribute to damage, however.

``The findings of this study demonstrate that nicotine causes acute endothelial dysfunction in long-term smokers and suggest that there may be other constituents of cigarette smoke that contribute to this adverse effect,'' Neunteufl and colleagues conclude."

I don't consider this proof that nicotine alone causes strokes and heart attacks. The nicotine gum has been on the market OTC for 20 years. We don't see any higher incidence of heart attacks and strokes among long-term users compared with former smokers who did not continue using the gum.

I was already aware of this one study and I chose my wording very carefully. I did not state "nicotine does not cause..." I worded it that "nicotine is not proven to cause..."

Could it? Possibly, but it is not proven to a scientific certainty.
 

SLDS181

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Aug 11, 2009
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Not exactly true. Nicotine has definitely been proven to be an artery hardening agent...hardened arteries lead to blockages and heart attacks. This is scientific fact.

Pretty sure its simply a vasoconstrictor - contracting the arteries, not hardening them, causing an increase in blood pressure, actually making it good for cases of hypotension.

I haven't had sudden dizziness since I started smoking, and my blood pressure is right where it should be, so I'm ok with it. YMMV. IANAD.
 
Last edited:

Talen

Senior Member
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Jun 23, 2009
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East Coast U.S.A/Thailand
Pretty major studies of the subject have been done by Daniel Catanzaro, PhD, of Cornell University's Weill Medical College and Dr. Benowitz chief of the Division of Clinical Pharmacology and Experimental Therapeutics at the University of California. Both have shown evidence of artery hardening as well as lipid level changes and stress on the heart and blood vessels.

Dr. Benowitz is most likely the leading authority on Nicotine in the United States and he has studied it through every delivery device that comes out including patches.
 

Surf Monkey

Cartel Boss
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May 28, 2009
3,958
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Sesame Street
It seems even vapers are missing it - yes, we know nicotine isn't "good" for us - but if it's the only REAL drawback to e-cigarettes as opposed to tobacco, and the KNOWN nastiness.....

I think my signature says it all:

It's not the caffeine in a latte that makes you fat. It's the milk. It's not the nicotine in a cigarette that kills you. It's the smoke.

We're not missing anything here. We know that there are risks involved with vaping. To continue the coffee analogy, nicotine is about as dangerous as caffeine. The problem with nicotine is that the primary delivery method is deadly. Coffee doesn't kill 1/2 of the people who use it. Neither does nicotine. Both have some negative health effects, but in comparison to the effects of breathing smoke all day, every day, they're minimal at best.
 

Vocalek

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I have been reading journal articles authored by Neal Benowitz for 2 decades. I just did a search on PubMed for "atherosclerosis" with "Benowitz" as author. There were 5 results, only two of which appeared to separate nicotine from smoke.

Prev Med. 1997 Jul-Aug;26(4):412-7.
The role of nicotine in smoking-related cardiovascular disease.
Benowitz NL.

Division of Clinical Pharmacology and Experimental Therapeutics, San Francisco General Hospital Medical Center, California 94110, USA. nbeno@itsa.ucsf.edu

Nicotine activates the sympathetic nervous system and in this way could contribute to cardiovascular disease. Animal studies and mechanistic studies indicate that nicotine could play a role in accelerating atherosclerosis, but evidence among humans is too inadequate to be definitive about such an effect. Almost certainly, nicotine via its hemodynamic effects contributes to acute cardiovascular events, although current evidence suggests that the effects of nicotine are much less important than are the prothrombotic effects of cigarette smoking or the effects of carbon monoxide. Nicotine does not appear to enhance thrombosis among humans. Clinical studies of pipe smokers and people using transdermal nicotine support the idea that toxins other than nicotine are the most important causes of acute cardiovascular events. Finally, the dose response for cardiovascular events of nicotine appears to be flat, suggesting that if nicotine is involved, adverse effects might be seen with relatively low-level cigarette exposures.

Am J Public Health. 1992 Mar;82(3):417-21.
Smokeless tobacco, cardiovascular risk factors, and nicotine and cotinine levels in professional baseball players.
Siegel D, Benowitz N, Ernster VL, Grady DG, Hauck WW.

Department of Epidemiology and Biostatistics, University of California, San Francisco.

BACKGROUND. The use of smokeless tobacco (ST), which has increased in popularity over the past 2 decades, results in considerable systemic exposure to nicotine. Nicotine might contribute to atherosclerosis by an effect on cardiovascular risk factors. METHODS. The effects of ST use on cardiovascular risk factors and cotinine and nicotine levels were studied in 1061 professional baseball players during spring training in 1988 and 1989. RESULTS. Of the study participants 477 (45%) were users. ST use was more common among Whites (55%) than among Blacks (29%) or Hispanics (21%), and users reported heavier consumption of alcohol (p less than .001) and had higher mean serum caffeine levels (p less than .001) than nonusers. ST users did not differ from nonusers in adjusted levels of systolic and diastolic blood pressure, pulse, and total or HDL-cholesterol. Among ST users, participants using snuff had higher mean serum cotinine levels than those who used chewing tobacco (p less than .001). There was no association between serum cotinine levels and adjusted levels of any cardiovascular risk factor studied. However, higher diastolic blood pressures were associated with higher mean serum nicotine levels (p = .02). CONCLUSIONS. Smokeless tobacco use has at most a modest effect on cardiovascular risk factors in young physically fit men.

PMID: 1536359 [PubMed - indexed for MEDLINE]
 

yvilla

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Nov 18, 2008
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Vocalek, thanks for your postings. I've also been trying to make people aware of this unfortunate confusion between the clearly demonstrated cardiovascular harm arising from smoking, and that which arises from nicotine itself, which is not clearly established at all. Below is another quote, regarding the differences seen in cardiovascular disease connected with smoking, as compared to the use of smokeless tobacco:

"Over the past 15 years, eight epidemiologic studies have examined the risk of cardiovascular diseases among ST users. Six of the studies found that ST users had no increased risk for heart attacks or strokes [47,90,97-100]. The other two reported modestly positive associations, with ST users having RRs of 1.2 and 1.4 [92,101], which are lower than those of smokers. In 2003, Asplund completed a comprehensive review of the cardiovascular effects of ST use [102]. He concluded that, in distinct contrast to smokers, ST users do not exhibit any significant differences from nonusers of tobacco with regard to the following measures of cardiovascular health: heart rate, blood pressure, cardiac output and maximal working capacity, levels of hemoglobin and hematocrit, leukocytes, antioxidant vitamins, fibrinogen, components of the fibrinolytic system, C-reactive protein and thromboxane A2 production. In addition, ST users did not show important smoking-associated vascular changes, including increased thickness of blood vessels and atherosclerotic plaque development. In summary, most of the medical and epidemiologic evidence documents that ST users do not have elevated risks for cardiovascular diseases." (Harm Reduction Journal | Full text | Tobacco harm reduction: an alternative cessation strategy for inveterate smokers)

As you noted, there are thousands of studies pointing to the death and disease caused by smoking, and nicotine has for the most part simply been found guilty by association. But studies focusing on the effects on the body of nicotine alone - separated from carbon monoxide and tar and all the other noxious elements of burning tobacoo - have been so few and far between, and difficult to find.
 

Vocalek

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And here is one on thecardiovascular risks of nicotine replacement. This study involved over 33,000 individuals:

Tob Control. 2005 Dec;14(6):416-21

Use of nicotine replacement therapy and the risk of acute myocardial infarction, stroke, and death.

Hubbard R, Lewis S, Smith C, Godfrey C, Smeeth L, Farrington P, Britton J.
Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK. Richard.Hubbard@Nottingham.ac.uk

OBJECTIVE: To determine whether nicotine replacement therapy (NRT) is associated with an increased risk of acute myocardial infarction, acute stroke, or death. DESIGN: Self control case series analysis of data from The Health Improvement Network (THIN) to estimate the relative incidence of myocardial infarction and stroke in four 14 day periods before and after the first prescription for NRT. SETTING: THIN is a computerised general practice database. SUBJECTS: Patients contributing data to THIN. INTERVENTIONS: Observational study of NRT. MAIN OUTCOMES: Acute myocardial infarction, acute stroke, and death. RESULTS: 33,247 individuals had been prescribed NRT, of whom 861 had had a myocardial infarction and 506 a stroke. There was a progressive increase in the incidence of first myocardial infarction in the 56 days leading up to the first NRT prescription (overall incidence ratio 5.55, 95% confidence interval (CI) 4.42 to 6.98), but the incidence fell after this time and was not increased in the 56 days after starting NRT (incidence ratio 1.27, 95% CI 0.82 to 1.97). The results were similar for second myocardial infarction and stroke, and for subgroups of people with pre-existing angina and hypertension. There were 960 deaths in our cohort during a mean follow up period of 2.6 years after starting NRT, with no evidence of an increased mortality in the 56 days after the NRT prescription (incidence ratio 0.86, 95% CI 0.60 to 1.23). CONCLUSIONS: The use of NRT is not associated with any increase in the risk of myocardial infarction, stroke, or death.
 

Vocalek

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A pubmed search using these parameters: (cardiovascular nicotine) AND (Catanzaro[Auth]) located one abstract. The study subjects were mice, and all were exposed to tobacco smoke.

Cardiovasc Toxicol. 2007;7(3):192-201

Potentially reduced exposure cigarettes accelerate atherosclerosis: evidence for the role of nicotine.

Catanzaro DF, Zhou Y, Chen R, Yu F, Catanzaro SE, De Lorenzo MS, Subbaramaiah K, Zhou XK, Pratico D, Dannenberg AJ, Weksler BB.
Department of Cardiothoracic Surgery, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY, 10021, USA. dfcatanz@med.cornell.edu

The tobacco industry markets potentially reduced exposure products (PREPs) as less harmful or addictive alternatives to conventional cigarettes. This study compared the effects of mainstream smoke from Quest, Eclipse, and 2R4F reference cigarettes on the development of atherosclerosis in apolipoprotein E-deficient (apoE -/-) mice. Mice were exposed to smoke from four cigarette types for 12 weeks beginning at age of 12 weeks, and in a separate study for 8 weeks, beginning at age of 8 weeks. In both studies, mice exposed to smoke from high-nicotine, high-tar Quest 1, and 2R4F cigarettes developed greater areas of lipid-rich aortic lesions than did non-smoking controls. Exposure to smoke from the lower-nicotine products, Eclipse, and Quest 3, was associated with smaller lesion areas, but animals exposed to smoke from all of the tested types of cigarette had larger lesions than did control animals not exposed to smoke. Urinary levels of isoprostane F2 alpha VI, increased proportionally to cigarette nicotine yield, whereas induction of pulmonary cytochrome P4501A1 was proportional to tar yield. Lesion area was associated with both nicotine and tar yields, although in multiple regression analysis only nicotine was a significant predictor of lesion area. Smoke exposure did not alter systolic blood pressure (SBP), heart rate (HR), blood cholesterol, or leukocyte count. Taken together, these observations suggest that smoking may accelerate atherosclerosis by increasing oxidative stress mediated at least in part via the actions of nicotine.
 

Vocalek

CASAA Activist
Supporting Member
ECF Veteran
Revised Version:

Are there people in your life who are tobacco smokers? Have they tried time and again to quit, without success? Do you wish there was some way you could help them stop?

What if there was an invention that would allow many, if not most, of the 45 million American smokers to quit—without any desire to go back to tobacco?

And what if very powerful groups were trying to force this product off the market by inaccurate accusations and deceptive claims about potential harm? Is that ethical? Is that in the best interests of public health?

The “electronic cigarette" is battery-operated and delivers vaporized nicotine. There is no tar, no particulates, no ash, no carbon monoxide, no risk of passive smoking, and no unpleasant odor. It is marketed to current smokers as a temporary alternative to smoking tobacco; but in one survey, 73% of e-cigarette users reported that they have completely quit smoking tobacco cigarettes.

This is an amazing success rate. But health organizations, anti-smoking groups, and the FDA appear to be doing their best to make sure that tobacco smoking remains the most popular source of nicotine.

So if you care about the life and the health of someone who smokes, please help.

•Visit the Electronic Cigarette Petition site and add your name to the nearly 13,000 people have signed: http://www.thepetitionsite.com/1/keep-life-saving-electronic-cigarettes-available.

•Write to your elected federal officials, including President Obama, and ask them to take action to keep these life-saving devices available. You can find contact information for government officials here: Contact Elected Officials: USA.gov

•Tell the FDA how you feel about their ethics and their distorted, incomplete, and misleading statement. Tell Commissioner Hamburg that these products need to be kept on the market for the health and safety of those who might go back to tobacco without them and those who might quit smoking using them. margaret.hamburg@fda.hhs.gov

•If you contribute to the American Lung Association, the American Cancer Society, and/or the American Heart Association, tell them you believe that their “quit or die” approach is heartless and unethical.

•If you support anti-smoking groups, make sure they know that your beef is with tobacco, not with any product that helps people get off and stay off tobacco.

Most importantly, PASS THIS MESSAGE ON. Send it to everyone you know who is a smoker or who cares about someone who smokes.

Elaine Keller
Springfield, VA

More Information:

Comparison of Carcinogen Levels Shows that Electronic Cigarettes are Much Safer Than Conventional Ones
The Rest of the Story: Tobacco News Analysis and Commentary: Comparison of Carcinogen Levels Shows that Electronic Cigarettes are Much Safer Than Conventional Ones

Cigarettes kill, but it's not the nicotine or the tobacco. It's the smoke!
Tobaccoharmreduction.org

Electronic Cigarettes FAQ
Electronic cigarettes. (tobaccoharmreduction.org)
 
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