I'm using 40/60 and 30/70 PG/VG, and I vape the same way you're describing. I still have the 400 mesh that my Mini shipped with, and I don't have any problems with it.
I do find that I occasionally have to tip the PV down for a few seconds, when it starts tasting a little dry.
I'll be changing to a 325 wick when I build my next coil, just to see if it makes much difference.

