Houston, we have a problem...BE nic titration results

Status
Not open for further replies.
... the test kit when used properly is good for plus or minus 10% on unflavored eliquid bases.

... it represents a concentration range [where one can confidently say the liquid lies within].

Absolutely. The point though is for ordinary folk to be able to tell if their liquid is way out of synch with the label; and for this the kit will do a good job.
 

mlinky

ECF Guru
ECF Veteran
Verified Member
Nov 22, 2010
12,203
7,031
Kentucky
Yeah, but there is a possibilty, isn't there, of other batches also being affected. Their labeling was somewhat imprecise, if you recall, so that complicates everything. How does one recall bottles that were not labeled properly (or not labeled at all)?

You recall ALL OF IT. Having batch numbers and being able to do a limited recall protects the supplier too.
 

Switched

ECF Guru
ECF Veteran
Feb 18, 2010
10,144
2,544
Dartmouth, NS Canada
You recall ALL OF IT. Having batch numbers and being able to do a limited recall protects the supplier too.
Yup! That is exactly what happens when you do not keep accurate records. It is relatively cheap to recall batch X vice the hole lot IMO. Never try to save a few bucks, it will cost you more in the long run.
 
It quite does matter what the concentration is, dose makes the poison, and the half life of nicotine is so short, dose over time makes the poison.

The Nicotine's LD50 is .5-1mg/kg, as in 25mg-50mg for someone at 120lbs, 50mg-100mg for someone at 240lbs.
It's half life in the human body is 1hr.

The really bad stuff, ~270mg/ml would be diluted down to ~46.5mg/ml in 18mg/ml recipe. Maybe around 65mg/ml for 24mg? Which again, is consumed over time. What's in your system is cut by half every hour.

The worst nicotine poisoning I'm aware was a case where 40% nicotine was added to beef in 2003 with a net result in tests at 300 mg/kg. Out of the 100 people who injected the beef, only 2 were admitted to the ER. One for atrial fibrillation, one for nausea, vomiting, and complaint of rectal bleeding. One hospitalization, a pregnant woman with episodic vomiting.

I don't mean to dismiss the BE case as being trivial, it's not. Fortunately at the concentrations offered the net result is a toxic, not lethal. Those at the highest risk are the folks working with it who would need to take extra precautions to deal with this level.

What makes this issue dangerous is not so much the high levels of concentration per se, but the fact that the recipients don't know what they have.

Also, despite all the advice not to be so stupid, quite a few people will try a vape at full strength out of curiosity.

It just needs an accident (leak / spill) on top of unknown high concentration for calamity to occur.

+++

Even if the worst mislabelling is only ~3x, while death would be (very) unlikely, other concerns arise. People might persist in the use of a liquid that is far higher than normal and feel unwell; in susceptible people this could lead to fairly serious symptoms.
 
Last edited:

mlinky

ECF Guru
ECF Veteran
Verified Member
Nov 22, 2010
12,203
7,031
Kentucky
I'm trying real hard to keep this thread useful and within the TOS. I have made some "command decisions" about some things that are on the edge of what is normally allowed to preserve the usefulness of the information presented here. I may get over ruled by Angus or Roly at some point, but I have confidence that they see things the same way I do and that they will let this thread continue. All I ask is that people try to follow the "spirit of the law" and don't take my variances from normally allowed practices as carte blanche to go crazy.

Sir, yes sir! *snapping to attention*
 

retird

Vaping Master
ECF Veteran
Verified Member
Dec 31, 2010
5,133
5,862
North Side
In looking at the issue at hand, it seems(at least to me) that the relevant question is:

What Quality Control measures do ALL distributors of Nicotine Base and ALL vendors have in place to assure the product is as labeled. That, to me, is the bottom line....

I have e-mailed the vendors that I use and, at this point, am getting vague responses. I am beginning to think that Quality Control is an "exception" rather than "a rule".
 

mostlyclassics

Ultra Member
ECF Veteran
Verified Member
Thanks, Kurt, for all you're doing for the vaping community!

Kurt said, in response to my experiences with the eBay test kit,

Do not use too much indicator, however. It is a weak acid itself, and too much will affect the end point volume. Which way depends on the indicator and what you are titrating, but this is a general rule of thumb. Amount of base being titrated is also important, and if the In amount is comparable to the base, it really changes things. Two drops should be all you use, even if BB is a difficult end point to see.

BTW, end point is where the color changes. Equivalence point is where the base has been titrated exactly completely. These two can be rather different depending on these details.

Thanks for the cautionary note, Kurt. Maybe I should rerun the tests. But I was getting almost the same results with two drops (earlier) as I did with six drops (on Thursday, November 17). Maybe there's only an insignificant difference in pH between two drops and six drops of indicator when you're using a total of 3 ml. test liquid? (I sure dunno, since I'm way out over my skis here! I've only had high school inorganic chemistry and organic chemistry classes, and that was in 1965. I took rocks 101 and 102 in college to satisfy the hard-science distribution requirement.)

I wonder also about the light source and background used. In my case, I used a 13-watt squiggly fluorescent bulb (supposedly equivalent to a 60-watt incandescent bulb) from about four feet over my shoulder and viewed the cylinder against a sheet of stark-white paper about a foot behind the cylinder. Is it possible that different light (say, an LED flashlight or sunlight) and/or a different background would show a slightly different endpoint?
 

Quick1

Ultra Member
ECF Veteran
Feb 11, 2010
2,684
280
USA
Reminds me a lot of the 60's... We could whip up a mass protest at any time with some dramatics. This is a valid, serious issue. But it's not a new issue and it's not something no one was aware of. "What's in that juice?", "What materials was that carto made from?", ... no traceability, no controls, do we want regulation? how does one self regulate when droves will flock to buy the one that's $0.10 cheaper. That sort of thing. Let's try to keep the dramatics/half truths/attention grabbers in check as they only undermine the effort to deal with an important issue right?

There are bottles out there at ~10x normal concentration, from which just a fraction of 1 ml could kill. A newbie could get a cart leak and unknowingly or by reaction swallow it. At 24mg you'd almost certainly survive; at 240mg you may well not.
Really? You're willing to just make that assertion that there are bottles out there at ~10x? I've only seen claims of 2x to 2.5x what they were labeled. What is the "normal" concentration for buying liquid nicotine in bulk? Do newbies really order 100mg nic? Are people really handling what they think is 100mg nic with no care or precautions? Cart leak?... I thought I was only vaping 100mg nic and my cart leaked 240mg nic...? Serious problem yes. I think people are capable of grasping the gravity of the situation without the dramatics.

A 220mg was discovered labeled as much lower (the x2.7 you mention). What I said was that 240mg is 10x what most normally vape; never said it was 10x the label.
Right... not many people vape straight liquid nic. Even fewer vape 100mg liquid nic.

On a totally unrelated subject if the future shows that BE is indeed a private residence, then that is worrisome indeed, when folks thought they were purchasing thier goods from a reputable company.
Really? Business run in private residence ==> disreputable business?

Since I was leading the panel discussion I'd like to point out that, like you, the panelist in question may not have been aware of RTS' source of nicotine. So claiming that the panelist lied to you is a little extreme. It was a round table discussion, with people with various levels of expertise, and the show was not about RTS so preparation for the show did not include research on RTS.
The panelist didn't constrain their statement to RTS did they? I kind of heard something to the effect of "NO vendors source their liquid nic from the US"?

Also, despite all the advice not to be so stupid, quite a few people will try a vape at full strength out of curiosity.
Darwin award?

In looking at the issue at hand, it seems(at least to me) that the relevant question is:

What Quality Control measures do ALL distributors of Nicotine Base and ALL vendors have in place to assure the product is as labeled. That, to me, is the bottom line....

I have e-mailed the vendors that I use and, at this point, am getting vague responses. I am beginning to think that Quality Control is an "exception" rather than "a rule".

Thank you! on point.

Major factor is cost. Small operations need high margins on low volume. Large operations kind of imply complying with regulations and approvals and huge initial investment in an uncertain (and relatively small) market. On our side there are the droves who flock to the $0.10 per unit cheaper price... Without regulation it can only be market driven. People need to vote with their dollars and they must be willing to spend more of them. I only use a couple of the old, very well established vendors that I trust for all my stuff. They tend to charge a bit more but I figure I'm getting my money's worth.
 

Switched

ECF Guru
ECF Veteran
Feb 18, 2010
10,144
2,544
Dartmouth, NS Canada
In looking at the issue at hand, it seems(at least to me) that the relevant question is:

What Quality Control measures do ALL distributors of Nicotine Base and ALL vendors have in place to assure the product is as labeled. That, to me, is the bottom line....

I have e-mailed the vendors that I use and, at this point, am getting vague responses. I am beginning to think that Quality Control is an "exception" rather than "a rule".
Not for long :) In the mean time let your wallet rule!!!
 

ScottB

Ultra Member
ECF Veteran
Oct 23, 2010
1,159
681
Goin' Mobile... eeh ooh, beep beep!
Reminds me a lot of the 60's... We could whip up a mass protest at any time with some dramatics. This is a valid, serious issue. But it's not a new issue and it's not something no one was aware of. "What's in that juice?", "What materials was that carto made from?", ... no traceability, no controls, do we want regulation? how does one self regulate when droves will flock to buy the one that's $0.10 cheaper. That sort of thing. Let's try to keep the dramatics/half truths/attention grabbers in check as they only undermine the effort to deal with an important issue right?

<snip>

^^^ This ^^^

Histrionics, what-if's, hyperbole, and sensationalism serves no one. The issue is big enough on its own without such things.
 
Last edited:
Let's try to keep the dramatics/half truths/attention grabbers in check as they only undermine the effort to deal with an important issue right?

I am pointing out the very real dangers because some people do not seem to realise the gravity involved. "Darwin award"?? People don't know what they have - so how can they determine the risk?

This isn't the time for trivialising. You call it dramatic; I call it serious.

There are a number of important issue surrounding QC; but there is also an ongoing situation where the issue has 'gone live'.

I wrote : "There are bottles out there at ~10x normal concentration" - maybe it is not the clearest sentence but reasonably easy to see that I mean 10x normal use concentration; it clearly doesn't say 10x the label. So don't twist words to make a point that doesn't exist.
 
Last edited:

Switched

ECF Guru
ECF Veteran
Feb 18, 2010
10,144
2,544
Dartmouth, NS Canada
*SNIP

Really? Business run in private residence ==> disreputable business?
Call it what you may... Box Elder Chemical Company would lead one to believe otherwise, wouldn't you think. I hope they do have a real company with proper protocols in place. However as discussed and allured to, there is serious doubt with regards to the following...

BE.jpg
click to enlarge
 

cozzicon

Ultra Member
ECF Veteran
Verified Member
Jun 19, 2010
2,564
900
Chicago IL
The panelist didn't constrain their statement to RTS did they? I kind of heard something to the effect of "NO vendors source their liquid nic from the US"?

Just to be clear, I'm responding because the issues surrounding this are important.

First, snipping one small paragraph out of what I wrote is misleading and changes the meaning of the passage (that's here so you know I'm not willing to dodge the question- and I'm willing to address it elsewhere).

Second, I'd like commentary and criticism regarding the interviewer or VapeTV to no longer be side tracking this thread. The crowd-sourcing here is too important. If folks want to start another thread to offer constructive criticism I'm fine with that- and will willingly answer questions (any questions) regarding the interview if they exist.

The above does not apply if the information pulled from the interview is germane to the research process at hand.
 
Last edited:

thehangdude

ECF Guru
ECF Veteran
Apr 17, 2011
11,437
21,721
63
Terre Haute, IN
In looking at the issue at hand, it seems(at least to me) that the relevant question is:

What Quality Control measures do ALL distributors of Nicotine Base and ALL vendors have in place to assure the product is as labeled. That, to me, is the bottom line....

I have e-mailed the vendors that I use and, at this point, am getting vague responses. I am beginning to think that Quality Control is an "exception" rather than "a rule".

I have had almost instant replies from the vendors I contacted. I would be very concerned if your vendor has not replied, or responds vaguely.
 

mjradik

Senior Member
ECF Veteran
Verified Member
Sep 8, 2011
184
45
Columbia, MD
It quite does matter what the concentration is, dose makes the poison, and the half life of nicotine is so short, dose over time makes the poison.

The Nicotine's LD50 is .5-1mg/kg, as in 25mg-50mg for someone at 120lbs, 50mg-100mg for someone at 240lbs.
It's half life in the human body is 1hr.

The really bad stuff, ~270mg/ml would be diluted down to ~46.5mg/ml in 18mg/ml recipe. Maybe around 65mg/ml for 24mg? Which again, is consumed over time. What's in your system is cut by half every hour.

I don't mean to dismiss the BE case as being trivial, it's not. Fortunately at the concentrations offered the net result is a toxic, not lethal. Those at the highest risk are the folks working with it who would need to take extra precautions to deal with this level.

I disagree with the statement that “I don't mean to dismiss the BE case as being trivial, it's not. Fortunately at the concentrations offered the net result is a toxic, not lethal.”

According to Wikipedia Nicotine - Wikipedia, the free encyclopedia a lethal dose can be 40-60mg for non smokers and 80-120mg for smokers… Depending on the weight of the person. I’m sure If you ingest it, its less lethal because of the stomach acid counter acting the base in the nicotine, and less gets in your bleed stream. And yes if you vape 40-60mg you will get sick before you get to the lethal doses.

But what if your DIY’er making liquid, and you spill some on you. If you soak just 0.5ml of 270mg nic into your skin, that IS lethal. Add to that the fumes you will get while working with it. And if you THINK your are working with 50-100mg, your less likely to be as causios than if you KNEW you were working with 270mg. I personally only work with <50mg nic when doing DYI, but I did work with a higher mg batch by mistake a while ago, and started to feel the effects just by the fumes cutting it down.
 
Last edited:

cozzicon

Ultra Member
ECF Veteran
Verified Member
Jun 19, 2010
2,564
900
Chicago IL
I disagree with the statement that “I don't mean to dismiss the BE case as being trivial, it's not. Fortunately at the concentrations offered the net result is a toxic, not lethal.”

According to Wikipedia Nicotine - Wikipedia, the free encyclopedia a lethal dose can be 40-60mg for non smokers and 80-120mg for smokers… Depending on the weight of the person. I’m sure If you ingest it, its less lethal because of the stomach acid counter acting the base in the nicotine, and less gets in your bleed stream. And yes if you vape 40-60mg you will get sick before you get to the lethal doses.

But what if your DIY’er making liquid, and you spill some on you. If you soak just 0.5ml of 270mg nic into your skin, that IS lethal. Add to that the fumes you will get while working with it. I personally only work with <50mg nic when doing DYI, but I did work with a higher mg batch by mistake a while ago, and started to feel the effects just by the fumes cutting it down.

I'd have to agree with you. A friend of mine acquired 300mg nic in an attempt to cut costs and ended up in a cardiac ward form the fumes.

Not to be played with.
 
Status
Not open for further replies.

Users who are viewing this thread