Reference for paper where nicotine was chronically adminmistered

[mosspa]

In several forums and threads here, references to studies where nicotine was chronically administered to non-smokers for some number of days followed by no withdrawal effects were given. Does anybody have those references? If so, could you please post them.

 

[sofarsogood]

In several forums and threads here, references to studies where nicotine was chronically administered to non-smokers for some number of days followed by no withdrawal effects were given. Does anybody have those references? If so, could you please post them.

I posted a couple of answers in the other thread including this one naming a Dr. Paul Newhouse.
http://www.tampabay.com/news/health/study-finds-nicotine-safe-helps-in-alzheimers-parkinsons/2175396

 

[sofarsogood]

Is this the study you are looking for? Nicotine treatment of mild cognitive impairment: A 6-month double-blind pilot clinical trial It's refered to in this article
Is Nicotine Really All That Addictive?
"Some evidence of this type can arguably be found in trials of nicotine for its potential benefits for other conditions, such as this one looking at whether it could help with mild cognitive impairments (answer: possibly). By the end of the study, 34 non-smokers had been on 15 mg of nicotine per day in the form of patches, but none reported any withdrawal symptoms, and all stopped using the patches. Someother studies have also looked at nicotine as a potential treatment for other conditions in never-smokers with no reports of dependence. However, evidence of this type is ultimately very limited, and since none of these studies specifically set out to investigate dependence in never-smokers, it’s more like anecdotal evidence than anything."

 

[Alien Traveler]

Is this the study you are looking for? Nicotine treatment of mild cognitive impairment: A 6-month double-blind pilot clinical trial

It's a nice paper. The only (but improtant) drawback is that most of the subjects were former smokers. Once a smoker...