Vaping nicotine as a never-smoker, why not?

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VNeil

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No one really believes that anymore than most don't believe modern day snake oil salesmen...
For a second there I actually thought you were attempting to engage in an intelligent discussion. But I was obviously wrong.
 

VNeil

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Not necessarily. Their brains will recognize the absence of nicotine, and reinforce any incorrect belief they have that nicotine is responsible for their 'dependence'. Expectancy is an amazing thing.

Here is a good example. About 20 years ago, I was the principal neuroscientist on a mostly-government scientist task force looking into the etiology of Multiple Chemical Sensitivity (i.e., when very low concentrations of various odiferous compounds [mostly organic solvent based] cause afflicted persons to experience many, sometimes very severe symptoms, presumably after some initial chemically sensitizing event or exposure]. Having observed relatively severe reactions of these people to very low concentrations of gasoline, perfume, and even scented soap, I initially drank the kool-aid and started a research program in my own lab looking at the potential for nasal epithelium receptors to directly sensitize the brain's limbic system (unlike any other sensory modality, there is a direct pathway from the smell organ to the amygdala (a nucleus of the limbic system responsible for, among other things, regulating emotional responses). Then, one day I attended a symposium that was largely attended by persons with MCS. All presenters were given instructions not to use scented soap or perfume/cologne before attending the meeting because we would be in close proximity to the MCS patients during a social event that was scheduled for after the formal program. Well, I am somewhat a creature of habit, especially at 6:00 am when I am functioning on about three hours of sleep, so I took a shower that morning using the hotel-provided soap (scented), and, without thinking, I applied a very liberal dose of my favorite cologne (which when I am wearing it, my technicians tell me they can 'smell' me coming from about 10 feet away). I went to the symposium, gave my talk, and then freely mingled with the MCS patients afterward. Not one of them reacted to my concentrated mixture of "smells". As it turned out, the MCS patients were advised that they need not worry about wearing respirators, oxygen tanks, or any other 'crutches' they used to 'survive' in the real world, because we (the presenters) were all medical professionals and would be scent free. Thus, these people had a strong expectancy that we would not be 'harmful' to them, and that we 'were on their side'. Their expectancies ameliorated their predicted responses to my "odors".

Well, to make a long story even longer, about three years later we had a final meeting of the task force and produced a document that was submitted to the Agency for Toxic Substances and Disease Registry (ATSDR) and the EPA. About a year after that, the clinical diagnosis for what had been called MCS was changed to Idiopathic Environmental Intolerance (i.e., a reaction to odors that has no definable physical cause).

The brain is a wondrous organ. It is capable of reorganizing input to meet its own specific needs. So, if it 'believes' something is the cause of an effect, it reorganizes its inputs to assure itself that it is correct. This is why I believe that nicotine dependence is "all in your head"
IOW the power of propaganda
 
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VNeil

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Not necessarily. Their brains will recognize the absence of nicotine, and reinforce any incorrect belief they have that nicotine is responsible for their 'dependence'. Expectancy is an amazing thing.

Here is a good example. About 20 years ago, I was the principal neuroscientist on a mostly-government scientist task force looking into the etiology of Multiple Chemical Sensitivity (i.e., when very low concentrations of various odiferous compounds [mostly organic solvent based] cause afflicted persons to experience many, sometimes very severe symptoms, presumably after some initial chemically sensitizing event or exposure]. Having observed relatively severe reactions of these people to very low concentrations of gasoline, perfume, and even scented soap, I initially drank the kool-aid and started a research program in my own lab looking at the potential for nasal epithelium receptors to directly sensitize the brain's limbic system (unlike any other sensory modality, there is a direct pathway from the smell organ to the amygdala (a nucleus of the limbic system responsible for, among other things, regulating emotional responses). Then, one day I attended a symposium that was largely attended by persons with MCS. All presenters were given instructions not to use scented soap or perfume/cologne before attending the meeting because we would be in close proximity to the MCS patients during a social event that was scheduled for after the formal program. Well, I am somewhat a creature of habit, especially at 6:00 am when I am functioning on about three hours of sleep, so I took a shower that morning using the hotel-provided soap (scented), and, without thinking, I applied a very liberal dose of my favorite cologne (which when I am wearing it, my technicians tell me they can 'smell' me coming from about 10 feet away). I went to the symposium, gave my talk, and then freely mingled with the MCS patients afterward. Not one of them reacted to my concentrated mixture of "smells". As it turned out, the MCS patients were advised that they need not worry about wearing respirators, oxygen tanks, or any other 'crutches' they used to 'survive' in the real world, because we (the presenters) were all medical professionals and would be scent free. Thus, these people had a strong expectancy that we would not be 'harmful' to them, and that we 'were on their side'. Their expectancies ameliorated their predicted responses to my "odors".

Well, to make a long story even longer, about three years later we had a final meeting of the task force and produced a document that was submitted to the Agency for Toxic Substances and Disease Registry (ATSDR) and the EPA. About a year after that, the clinical diagnosis for what had been called MCS was changed to Idiopathic Environmental Intolerance (i.e., a reaction to odors that has no definable physical cause).

The brain is a wondrous organ. It is capable of reorganizing input to meet its own specific needs. So, if it 'believes' something is the cause of an effect, it reorganizes its inputs to assure itself that it is correct. This is why I believe that nicotine dependence is "all in your head"
I would have to ask one question about the MCS story. Since they should have smelled you 10 feet away, why was that not a que? Or do you think their expectations overpowered their noses?
 
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englishmick

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Well, to make a long story even longer, about three years later we had a final meeting of the task force and produced a document that was submitted to the Agency for Toxic Substances and Disease Registry (ATSDR) and the EPA. About a year after that, the clinical diagnosis for what had been called MCS was changed to Idiopathic Environmental Intolerance (i.e., a reaction to odors that has no definable physical cause).

For some reason your assessment of MCS as idiopathic reminds me of the reaction of the medical and scientific establishment to Agent Orange Syndrome.

Scientists tend to be very sure they are right, and that their experiments leave no room for doubt, at least in their own minds. I think there's a pretty good chance that sometime soon a panel of government scientists is going to decide that vaping is really bad for your health.
 

mosspa

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IOW the power of propaganda

Well maybe, depending on how where you are applying propaganda and the source thereof. My main point is the power of expectancy over reality. If these people were truly sensitive to perfume/soap odors, they should have reacted to me. They didn't because they believed that as a responsible medical scientist I would never endanger them. This is almost perfectly analogous to the ex-smoker that believes he/she was made dependent on nicotine because of smoking. The brain makes it appear to those individuals as the truth behind their 'condition'. Because nicotine has no capacity to induce dependence, their beliefs are incorrect, but the brain compensates and continually provides the necessary proof to maintain the belief.
 

mosspa

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I would have to ask one question about the MCS story. Since they should have smelled you 10 feet away, why was that not a que? Or do you think their expectations overpowered their noses?

The later, actually. The brain attends to what it thinks is important to attend to. In the case of the 10 ft reported by the technicians. I was the 'boss' and if you can smell the boss coming from 10 feet, that has important consequences. Since the MCS patients had no reason to consider my smell, they just didn't. It is a rather bizarre population in many other aspects. They tend to be introverted and needy, and I think I met several that were either borderline or truly schizophrenic.
 

VNeil

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Well maybe, depending on how where you are applying propaganda and the source thereof. My main point is the power of expectancy over reality. If these people were truly sensitive to perfume/soap odors, they should have reacted to me. They didn't because they believed that as a responsible medical scientist I would never endanger them. This is almost perfectly analogous to the ex-smoker that believes he/she was made dependent on nicotine because of smoking. The brain makes it appear to those individuals as the truth behind their 'condition'. Because nicotine has no capacity to induce dependence, their beliefs are incorrect, but the brain compensates and continually provides the necessary proof to maintain the belief.

If you tell a person a lie, over an over, thousands of times, he will come to believe it. Do that to 10,000 people and they will reinforce the lie by repeating it to each other, over and over. How can everyone be wrong about something?

That's propaganda, and you see it all over this site, although the targets will never acknowledge it.

And I suspect you are saying the same thing with nicotine dependence, if you are correct in your hypothesis.

ETA: Typically malicious intent is ascribed to the purveyor of propaganda. In this case it may have been a simple mistake but regardless of motive that doesn't change the end result.
 
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mosspa

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For some reason your assessment of MCS as idiopathic reminds me of the reaction of the medical and scientific establishment to Agent Orange Syndrome.

Scientists tend to be very sure they are right, and that their experiments leave no room for doubt, at least in their own minds. I think there's a pretty good chance that sometime soon a panel of government scientists is going to decide that vaping is really bad for your health.

You are very wrong, here. No one has ever disputed that there was a lot of harm that was inflicted by agent orange, and if we knew as much about the toxic and reproductive effect potential of dioxins in 1970 as we do now we never would have used it (similar to the way we never used paraquat again after the initial effects in us cannabis users were uncovered). The things that are argued as idiopathic are things that have never been connected with dioxins, even after experimental trials. One of these, I remember, was one soldier's interstitial fibrosis. After extensive investigation it was conclusively determined that it was not caused by service-connected dioxin exposure, and that it was idiopathic, in that it apparently had no external physical cause (i.e., it was probably unique to his particular genome). The government had no reason to 'lie' about this, because cause is not a qualification for a service-connected disability.
 
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mosspa

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If you tell a person a lie, over an over, thousands of times, he will come to believe it. Do that to 10,000 people and they will reinforce the lie by repeating it to each other, over and over. How can everyone be wrong about something?

That's propaganda, and you see it all over this site, although the targets will never acknowledge it.

And I suspect you are saying the same thing with nicotine dependence, if you are correct in your hypothesis.

You are, of course, correct. There is much of that sort of propaganda. But what I'm suggesting is that propaganda only reinforces what the individual has long thought. Its existence makes it all that easier for the brain to set up and expectation of withdrawal symptoms if they remove nicotine. After all the propaganda supports their notion that they are addicted to nicotine.
 

zapped

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For a second there I actually thought you were attempting to engage in an intelligent discussion. But I was obviously wrong.


All arguments aside, youre not going to change peoples minds on way or another on this subject, so have fun beating this dead horse to death for another 31 pages.

When liberal views like this contribute to tighter restrictions on vaping, dont say you werent warned.
 
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mosspa

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similar to the way we never used paraquat again after the initial effects in US ........ users were uncovered/QUOTE]

Mods, look at that phrase and ask yourself whether or not the people you are paranoid about might more likely think you have something to hide and have adopted a CYA strategy. Clearly, there is no advocacy implied in that phrase, it's just a statement of fact.
 
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WharfRat1976

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Most people on this forum are vaping to reduce or eliminate tobacco use, and I would also predict that most of those people were very long duration tobacco users (15 years+). Again, a habit strength hypothesis fits this much better than a physical dependence hypothesis.
Pure ........ above.
 

WharfRat1976

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For a second there I actually thought you were attempting to engage in an intelligent discussion. But I was obviously wrong.
If you could point me to anything intelligent by all means. I think the nic has affected your cerebral cortex and cognitive acumen...lol
 
Intriguing read.
Thanks op.
Thanks for reading!

Not sure if you would be better at Fiction or Non-Fiction ... but dude, you got some writing skills that are worth honing into some dough.
Sent via iPhone
Hahaha, thanks man. English is my fourth language, but I definitely have to look into it sooner or later as I've been pondering on the idea of writing for a while.

Vaping melatonin would be a waste of time. Melatonin is a relatively fragile molecule. It won't even survive the gut (which is why oral, non-sublingual, melatonin doesn't get into the bloodstream). I seriously doubt it would survive being boiled :)

Yep, speaking of which, if anyone is considering melatonin due to sleep difficulties, after using it for years I have found 0.1 to 0.3 mg of sublingual melatonin to work best, with absolutely no side effects nor tolerance even with every day use.

[I'm a lucid dreamer, BTW, and I highly recommend learning the techniques that enable one to dream lucidly]. The brain is capable of some really amazing things.

Other lucid dreamer here, you guys should definitely check it out. Speaking of which I highly recommend Stephen LaBerge's "Exploring the World of Lucid Dreaming" if the subject interests you.

Symptoms of withdrawal are a sure sign of addiction. Take the mod away from most people on this forum for a few days and see what happens...

That might be due to them having developed a behavioral addiction towards vaping, rather than nicotine itself, much like some people get addicted to eating junk food compulsively, gambling, video games, the internet etc.
 

stevegmu

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That might be due to them having developed a behavioral addiction towards vaping, rather than nicotine itself, much like some people get addicted to eating junk food compulsively, gambling, video games, the internet etc.

Take their nic away and see what happens. Do you vape 0 nic?
 
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motordude

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All arguments aside, youre not going to change peoples minds on way or another on this subject, so have fun beating this dead horse to death for another 31 pages.

When liberal views like this contribute to tighter restrictions on vaping, dont say you werent warned.
Disagreed.
I keep my mind open in all discussions, if that makes me a liberal then ok.
 

Jman8

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You are, of course, correct. There is much of that sort of propaganda. But what I'm suggesting is that propaganda only reinforces what the individual has long thought. Its existence makes it all that easier for the brain to set up and expectation of withdrawal symptoms if they remove nicotine. After all the propaganda supports their notion that they are addicted to nicotine.

Changing lanes, and not trying to veer too far off the path (or topic), but am curious what a medical scientist such as yourself believes about the propaganda assertion (or data point, if you prefer) that 480,000 people die annually from tobacco smoking, in the U.S.?

I am inclined to be forthright with my personal belief (that I would not say is strictly opinion) that the number is greatly inflated / made up. But am curious what you think / believe.
 

mosspa

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Changing lanes, and not trying to veer too far off the path (or topic), but am curious what a medical scientist such as yourself believes about the propaganda assertion (or data point, if you prefer) that 480,000 people die annually from tobacco smoking, in the U.S.?

I am inclined to be forthright with my personal belief (that I would not say is strictly opinion) that the number is greatly inflated / made up. But am curious what you think / believe.

It sounds inflated to me as well. However, it may not be as far off I would have imagined, as I look at the CDC mortality and morbidity statistics from 2011. They reported that 207,339 people had lung cancer and 156,953 people died of it. Now 157K (and that would assume 100% of all lung cancer deaths were in smokers) is clearly a lot less 480K. I also looked at lung function and COPD mortality rates and got another 3000 there. Where they really get a break is that the cardiopulmonary mortality rate was 880K. So, well over a million people died of diseases that have been linked to smoking. Are a little less than half of them attributable to smoking? It's anybody's guess. But, in that 480K number I'm sure there were many cases where a smoking-related bias was a factor in death classification.
 
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