1996 study: nicotine in its pure form

[nojoyet]

An interesting read.

1996;58(16):1339-46.
Long-term effects of inhaled nicotine.

Waldum HL, Nilsen OG, Nilsen T, Rørvik H, Syversen V, Sanvik AK, Haugen OA, Torp SH, Brenna E.
Department of Medicine, University Hospital, Tronheim, Norway.
tobacco smoking has been reported to be associated with increased risk of cardiovascular disease and cancer, particularly of the lungs. In spite of extensive research on the health effects of tobacco smoking, the substances in tobacco smoke exerting these negative health effects are not completely known. Nicotine is the substance giving the subjective pleasure of smoking as well as inducing addiction. For the first time we report the effect on the rat of long-term (two years) inhalation of nicotine. The rats breathed in a chamber with nicotine at a concentration giving twice the plasma concentration found in heavy smokers. Nicotine was given for 20 h a day, five days a week during a two-year period. We could not find any increase in mortality, in atherosclerosis or frequency of tumors in these rats compared with controls. Particularly, there was no microscopic or macroscopic lung tumors nor any increase in pulmonary neuroendocrine cells. Throughout the study, however, the body weight of the nicotine exposed rats was reduced as compared with controls. In conclusion, our study does not indicate any harmful effect of nicotine when given in its pure form by inhalation.

PMID: 8614291 [PubMed - indexed for MEDLINE]

 

[beckah54]

Good read!!

 

[NickJuice]

Wow!! Do you have a link to the full study?

 

[ECS-Mike]

I like the part about 'we dont know why breathing smoke causes cardiovascular disease and heart disease'.

Hmm...why would filling up the sacks in your lungs, making every peice of your cardio vascular system work harder to pull the same amount of air, cause premature failure...hmmm..thats a tough one...

 

[nojoyet]

Wow!! Do you have a link to the full study?

this is the link, I didn't check to see if there is any path to the complete study.
http://www.ncbi.nlm.nih.gov/pubmed/8614291

 

[solaar]

Once again, no surprise to me.
It's actually a well-known fact that healthy lungs can regenerate themselves quite fast. Assuming a non-lethal dose of non-carcinogenic but perhaps potentially toxic substances, the duration of recovery will eventually depend on the size of the particles that are inhaled and the ability of the body to absorb or even metabolise them.

Inhaling pure nicotine, we would certainly be talking about very small particles, in fact on the molecular nano scale. Apart from that nicotine has never been proven to be carcinogenic. Plus it's absorbed and metabolised. Why should there be any noticeable effect on the lungs?

Big city street dust and diesel fumes are most likely much more harmful to our respiratory system than nicotine vapour.

Now once the lungs are diseased we might face a totally different set of parametres but that's not what this study was about.

 

[Janetda]

There are several good studies there:

Permissive nicotine regulation as a complement to ... [BMC Public Health. 2005] - PubMed result
Estimating the health consequences of replacing ci... [Tob Control. 2003] - PubMed result

to name two.

 

[quovadis]

This is what i found on nicotine

Constriction
The heart is the most important muscle in the system. It is responsible for pumping blood to the whole body. Nicotine can increase your risk for cardiovascular diseases like strokes, heart attacks, heart disease, peripheral vascular disease and aneurysms. This happens as a result of blood vessels getting constricted. This blood vessel constriction can also cause impotence in men.

I wonder if vaping is included in the above statement?

 

[solaar]

This is what i found on nicotine

Constriction
The heart is the most important muscle in the system. It is responsible for pumping blood to the whole body. Nicotine can increase your risk for cardiovascular diseases like strokes, heart attacks, heart disease, peripheral vascular disease and aneurysms. This happens as a result of blood vessels getting constricted. This blood vessel constriction can also cause impotence in men.

I wonder if vaping is included in the above statement?

Most likely, but as with everything, it all depends on how much.

However, the evidence of any direct ill effects of nicotine on the lungs is still to be delivered. At any quantity, that is.

BTW caffeine, stress, alcohol excesses and sleep deprivation have the same effects on the cardiovascular system. Add to that an excessively unhealthy diet and meet the serial killer no 1 of the industrialised world.

Anti-smoking moralists are always the quickest to ignore the fact that food is still the ultimate killer, with more victims than smoking, alcohol and drugs together.

 

[Dacoopah]

Everyone who has ever eaten carrots, has eventually died.

 

[Debra]

Everyone who has ever eaten carrots, has eventually died.

LOL... You made me choke on my coffee.

 

[bassn99]

Some really good material out there. I have done a ton of research myself on the internet. Of course everyone knows if it's on the internet it TRUE....... I am going for my annual phyical in the morning and my doctor already knows I am vaping. I am going to ask when the blood work is tested to see if they can do an additional test for nicotine levels. I really won't have anything to compare these numbers to, but if I were a betting man (I am) I would think my numbers will be low.
We shall see, until someone can prove to me that I am doing MORE harm to my body than I was obviously doing with analogs, VAPING IS FOR ME.......

 

[robbiehatfield]

Everyone who has ever eaten carrots, has eventually died.

True, and they were better able to see it coming. LOL

Robbie

 

[Giantfan]

This is what i found on nicotine

Constriction
The heart is the most important muscle in the system. It is responsible for pumping blood to the whole body. Nicotine can increase your risk for cardiovascular diseases like strokes, heart attacks, heart disease, peripheral vascular disease and aneurysms. This happens as a result of blood vessels getting constricted. This blood vessel constriction can also cause impotence in men.

I wonder if vaping is included in the above statement?

I have to look at my own experience here as something positive. I have an out of whack heart rate, due to anxiety and mitral regurgitation. My heart has a tendency to beat really fast, and a lot of times I have high blood pressure.

When I smoked, my heart was in bad shape. Beating hard and fast all the time, pains, tightness etc.

Since beginning vaping about a month ago, I have to say that there has been no effect on my heart rate or blood pressure at all. So, while nicotine does what you mentioned above, so far my vaping experience shows me vaping nicotine has little effect.

This is great news obviously.

 

[Smoking Guns]

This is great news. I'm passing the article on to my wife!

 

[shadydan]

Very interesting article! Thanks for posting it.

 

[P3rplexity]

Everyone who has ever eaten carrots, has eventually died.

lmao, thanks, my monitor needed a good water washing anyways

 

[umop apisdn]

Very interesting read. I would like to see a study conducted on vaporized PG alongside this. If it goes well, it could prove responsible use of a PV would be a definitively better choice than smoking analogs.

 

[TaketheRedPill]

Everyone who has ever eaten carrots, has eventually died.

I wouldn't put much good faith in a study over 10 years old. 10 years ago, there weren't even any blackberrys or ipods.

and speaking of carrots, they're apparently not smoker-friendly. goggle beta carotene and smokers

TTRP

 

[firhill]

Throughout the study, however, the body weight of the nicotine exposed rats was reduced

Wish my body reacted the same as the rats' bodies.