I'm a bit confused by your question. I don't think the hardware cares about your nic levels, you just have to meet the requirements for the battery, mod, coil, etc. to vape safely.
As far as the nic levels and the vaping experience, I think it depends on your own taste and tolerances. I'm currently using original Berserker mini's with both plus and sub ohm coils in them. When I switched to rebuildables, I dropped from 18mg down to 6 mg juices and found that the nico-demons were happy with the drop compared to my older tech atomisers and Blu tanks. I consider myself to be a tootlepuffer, and run these between 6 and 10 watts, with the 1.2 coils at the 6W and the .7 coils at 10W. At the time I switched, I had heard that you could drop your nic levels with the more efficient rebuildables compared to the old tech coils.
Some of my flavors are better with the .7 setup and others are better with the 1.2's. My coils last pretty long compared to the drop ins, but some flavors gunk the coils faster than others. YMMV.