Fact: most states are trying to ban E-cigs
The use of e-Cigarette substantially decreased cigarette consumption without causing significant side effects in smokers not intending to quit (Home - ClinicalTrials.gov webcite number NCT01195597).
But there’s a powerful group working against this innovation — and it’s not Big Tobacco. It’s a coalition of government officials and antismoking groups who have been warning about the dangers of e-cigarettes and trying to ban their sale.
The controversy is part of a long-running philosophical debate about public health policy, but with an odd role reversal. In the past, conservatives have leaned toward “abstinence only” policies for dealing with problems like teenage pregnancy and ...... addiction, while liberals have been open to “harm reduction” strategies like encouraging birth control and dispensing methadone.
When it comes to nicotine, though, the abstinence forces tend to be more liberal, including Democratic officials at the state and national level who have been trying to stop the sale of e-cigarettes and ban their use in smoke-free places. They’ve argued that smokers who want an alternative source of nicotine should use only thoroughly tested products like Nicorette gum and prescription patches — and use them only briefly, as a way to get off nicotine altogether.
In 2010 Bullen et al. published the results of a crossover clinical trial in which e-cigarettes containing 0 mg. and 16 mg. of nicotine were compared with a nicotine inhaler and own-brand cigarettes among 40 smokers who had been abstinent overnight [85]. Bullen et al. reported that 16 mg. e-cigarettes and the inhaler produced the same reduction in desire to smoke and other withdrawal symptoms. Both products produced modest elevations in peak blood nicotine (1.3 and 2.1 ng/ml respectively) that were much lower than that produced by cigarettes (13.4 ng/ml). Compared with inhalers, e-cigarettes resulted in significantly less frequent mouth and throat irritation (88% vs. 38%). Bullen et al. concluded that the tested e-cigarettes were "well tolerated, acceptable to most users, rated significantly more pleasant to use than the inhalator, and in the first hour exhibited a pharmacokinetic profile more like the inhalator than a tobacco cigarette, without excess adverse events. These findings suggest potential to help people stop smoking in the same way as a nicotine inhalator."
In 2010 Eissenberg used a controlled puffing regimen and compared two brands of e-cigarettes with own-brand cigarettes, measuring blood nicotine levels, heart rate and craving among 16 smokers abstinent for 12 hours [86]. He concluded that the e-cigarettes "delivered little to no nicotine," and the measured increases in blood nicotine were very similar to those from Bullen et al. In addition, Eissenberg found that e-cigarettes "suppressed craving less effectively," although both brands produced reductions, one of which was significant at a single time point. Later in 2010 the same research group included these results in an expanded trial that included 32 smokers, but the conclusions remained essentially the same [87].