It's the other way around - smaller particles can penetrate into deeper tissues because of their size. Think of it like running water through a filter - the filter traps larger particles, while smaller particles like water molecules and ions pass right through.
Nevertheless, you are absolutely right about the way smoke interacts with our tissues versus vapor
yet, while much of the vapor is going to get absorbed along surfaces as it goes deeper into the lungs,
some of it will penetrate very deeply into lung tissue. This is based in studies done on aerosols.
However, the claim is that these particles will carry the
horribly dangerous chemicals provided by e-cigarette vapor deeply into the lungs, which can lead to disease via a cumulative effect over time. Yet, aside from the flawed carbonyl study cited in this article, there is no evidence that vapor particles contain hazardous chemicals at a high enough level to cause harm.
So there you have it - yes, vapor can penetrate deeply into lung tissue, but no, it will not cause a problem unless the vapor itself is hazardous, and that has not been proven.