Does that mean that you have to heat the PG/VG/Nic/Flavouring mixture while doing it? Surely it'd be difficult to separate out the effects of heating versus vacuum.
It depends on achievable pressure of the vacuum. i mean heated to warmish not hot
A pre warmed liquid will need less PSI to vapourise, However it is completely achievable to vaporize without warming it first but requires a lot more technical hardware.
You can use a syringe and some water to create a vacuum to see what i mean.
draw a little cold water (0.2ml) into medium 2ml syringe, block end off pull back plunger to create a vacuum it won't really do much. Repeat the experiment by using same amount of water and heat it so it is about 40c then try again you will see it bubble. repeat a last time with 85C water ( you will see it vaporize).
repeating the experiment with 5ml syringe (will be hard to pull back) and you will see that the larger vaccum creates more psi and has a similar effect to heating. Mix the two together more psi, more heat and bingo.
Although one thing highly highly important about heating PG or VG is as it has a very high boiling point (PG 180C VG 290C). Therefore
NEVER ever ever boil it (under normal atmospheric pressure) any thing that comes in contact with it whilst boiling will combust, or it will give you some very nasty burns!