Far as I understand it (and there's a lot I don't understand), you can forget about Nude Nicotine. Apparently, Alchem (Nic Select) already has FDA approval
FDA APPROVAL LETTER but I'm not clear on whether it's for the product or just the facility. Alchem probably has resources to obtain FDA approval, but who knows if they'll decide the cost of doing so is justifiable. Stands to reason that if the (DIY) market is lucrative enough (doubtful at this point) big pharma will go ahead and field a liquid nic product, but I'd expect prices to rise significantly from what we're paying now, among other hassles...imagine only being able to buy nic base only by prescription from a pharmacy.
But I wouldn't hold much hope that Nude Nicotine or Carolina Extracts would have the resources to obtain FDA approval.
There should be no issue with synthetic flavorings, VG/PG. Hence, we'll probably see a shift in DIY suppliers over the next few months to business models like Bull City. Flavors, PG, VG, bottles, lab equipment, and that's it.
NETs, tobacco absolutes...any flavor derived from real tobacco will probably also be gone, at least initially.
Just my best guesses though. I have not read all 499 pages yet, and may not be correctly interpreting what I have read.
Edit...I have my inquiry in with Nicotine River (nicselect vendor) as well.