Propylene glycol toxicity

[Kattdaddy]

I'm just curious how you knew they were about to poop, and later, how you knew they were constipated? Never mind, maybe I don't want to know!

Yes, that in itself gave me the proof I need to realize this guy is full of crap.... no pun intended. Notice he hasn't even made the attempt to explain what a few have posted for a response to question his supposed experiment. I certainly hope he washed his hands.........

 

[dee5]

"Yes, that in itself gave me the proof I need to realize this guy is full of crap"

Idoesmoking is a doctor, professor and researcher and he lives in India so there is a 12 hour time difference. Could be why he hasn't responded yet.

 

[5cardstud]

But that test is moot because the proylene Glycol was burnt in a burning cigarette not vaporized. How much of it was lost to burning or extreme heat versus how much is lost to low heat in vaporizing. And how many people do you know that put it in their cigarettes? I've heard of people putting alot of stuff in their smokes but never propylene glycol. But then I don't know alot of mice that smoke either.

 

[notsoogood]

Im with Doots, I think it say that effects of drying, etc were done after 42 days then the rats were back to normal even tho still exposed? Is that correct? Lotsa BIG words

So what are you???? A genius!!!??? I didn't understand a thing in that post! LOL I think I need to go back and_read_real_sllooowwwwlllyyyy. Maybe then I can figure it out!

 

[dee5]

While looking for something else, I found this. Has any one else posted it yet? I hope this link works:
Propylene glycol in e cigarettes might keep us healthy, says researchers

 

[Kattdaddy]

@Vocalek : Very helpful post.I believed from the day I heard and knew of e-cigs;its an alternative addiction.Like people sniff glue,nail polish remover and hundreds of other stuffs,its like that.e-cig helped me to stop analog cigs- the more dangerous one,I am happy for the fact.I had a WRONG impression,that the companies add something to e-liquid;so,I prepared e-liq in my lab (PG based).I concluded that PG vapor itself has the ability to make one addicted.I had to test it.It would sound inhuman,but I exposed 2 rabbits to PG vapor (5 minx4 times a dayx 4 days)-two after major meals,two before their defecation.On the 5th day,I stopped it.They were aggressive,a bit constipated too.The control rabbit (one) was exposed to water vapour.
The rabbits are in good health now,dont worry
I have no intension to make this report forwarded to any organization,for several reasons.
It is evident to me,I have to quit e-cig too for the benefit of not only my family,but for all who will be benefited by me,directly or indirectly.
Hope it helps some one.
By the way,PG vapor has a bronchodilator action too,(like albuterol (aka Salbutamol))-but the mechanism of action is different),so,asthmatics may find a "relief"-this is from my personal experience-I have asthma.But,I made a peripheral blood film of me,examined under microscope-I have noted the reduced Eosinophil count,reduced reticulocyte count,shift to left of neutrophil-an effect that is produced by high dose prolonged steroid use.
I need more opinion from the super specialists...

Eosinophil count refers to a blood smear test that measures the white cell content in the blood stream.Escalated counts indicate allergic diseases and infections.

The reticulocyte count refers to the measure of red cell rate of producion in the bone marrow.(used to determine anemia)

The shift to left of the neutrophil refers to an increase in the immature neutrophils released from production by the bone marrow in response to fighting infection, usually bacterial infection or inflammation.

This alone does not indicate other conditions he may have leading to such outcome. As a matter of fact, conducting real research by ethical guidelines usually require a subject to go through extensive testing to rule out precursors prior to experimentation. Nobody here knows whether he may have a condition causing this outcome outside of his exposure to PG vapor and to expect us to reason with his results is out of the question.

I only refer to the ethics of performing such research on ones' self as bias.... Such ethics are in place to guarantee that the research can be properly validated and there are reasons those guidelines are in place. Whether or not he is a doctor or professor is irrelevant, as it further proves that he should know better than to experiment on himself. Thus, making any findings unconclusive and unproven.

 

[voltaire]

And how many people do you know that put it in their cigarettes? I've heard of people putting alot of stuff in their smokes but never propylene glycol.

PG along with VG are actually quite common additives in analog cigarettes. Predictably, they help produce thicker smoke.

 

[V4Lis4me]

PG along with VG are actually quite common additives in analog cigarettes. Predictably, they help produce thicker smoke.

Exactly,
that is why the studies were conducted I presume. PG and VG are both common additives in the long list of 'regular' cig additives.

...so,
if you've smoked a cig, you've smoked a certain percentage of vg or pg additive..... but, nowhere near our consumption levels with ecigs.


and I may be wrong,
but I do believe that they were added to cigs to retain moisture content in the tobacco, not produce better smoke.

 

[Wireguy]

Thats one point he made. The other was PG is addicting. I suspect we would already know if it was or not given how many products it's used in.

The whole argument is sort of well...

Eosinophil count refers to a blood smear test that measures the white cell content in the blood stream.Escalated counts indicate allergic diseases and infections.

The reticulocyte count refers to the measure of red cell rate of producion in the bone marrow.(used to determine anemia)

The shift to left of the neutrophil refers to an increase in the immature neutrophils released from production by the bone marrow in response to fighting infection, usually bacterial infection or inflammation.

This alone does not indicate other conditions he may have leading to such outcome. As a matter of fact, conducting real research by ethical guidelines usually require a subject to go through extensive testing to rule out precursors prior to experimentation. Nobody here knows whether he may have a condition causing this outcome outside of his exposure to PG vapor and to expect us to reason with his results is out of the question.

I only refer to the ethics of performing such research on ones' self as bias.... Such ethics are in place to guarantee that the research can be properly validated and there are reasons those guidelines are in place. Whether or not he is a doctor or professor is irrelevant, as it further proves that he should know better than to experiment on himself. Thus, making any findings unconclusive and unproven.

 

[MaryMarcelle]

While looking for something else, I found this. Has any one else posted it yet? I hope this link works:

Wow!! I checked out this Link. Very informative and interesting. To think that vaping might actually serve as a better substitute for a flu shot! (which I wouldn't get anyway, but I know some people like to)

Thank you so much for sharing it!

 

[voltaire]

and I may be wrong,
but I do believe that they were added to cigs to retain moisture content in the tobacco, not produce better smoke.

If I remember correctly, I read that somewhere rather authoritative. It may have even been in the tobacco company documents that were released to the public, but I'm not sure. Either way, PG/VG in a cig does vaporize as it's heated by the cherry, so some volume of exhaled cigarette smoke is almost certainly PG/VG vapor. Ever notice how cigarette smoke is unlike any smoke produced by other means? That's the result of constant BT product testing and tweaking - they know a big part of the experience is from the exhale of thick "clouds". Not surprising at all that they would maximize that as much as possible.

 

[idoesmoking]

Eosinophil count refers to a blood smear test that measures the white cell content in the blood stream.Escalated counts indicate allergic diseases and infections.

The reticulocyte count refers to the measure of red cell rate of producion in the bone marrow.(used to determine anemia)

The shift to left of the neutrophil refers to an increase in the immature neutrophils released from production by the bone marrow in response to fighting infection, usually bacterial infection or inflammation.

This alone does not indicate other conditions he may have leading to such outcome. As a matter of fact, conducting real research by ethical guidelines usually require a subject to go through extensive testing to rule out precursors prior to experimentation. Nobody here knows whether he may have a condition causing this outcome outside of his exposure to PG vapor and to expect us to reason with his results is out of the question.

I only refer to the ethics of performing such research on ones' self as bias.... Such ethics are in place to guarantee that the research can be properly validated and there are reasons those guidelines are in place. Whether or not he is a doctor or professor is irrelevant, as it further proves that he should know better than to experiment on himself. Thus, making any findings unconclusive and unproven.

Many thanks to Kattdaddy and dee5 for explaining every thing.

I dont claim anything against e-cig nor support it.Yes I do like vaping too.

And for the member who wants to know,how I know the rabbits are constipated (sorry his name was few pages ago,and I cant remember)...its easy...rabbit's intestine is very delicate,they defaecate two times per 24 hours.First time they do it at night,its soft,unformed stool,they eat it (coprophagy)...second time they pass it during morning..its formed bead like,but separated from each other.If a rabbit is constipated,there is change in the volume,consistency,bead forming etc.Constipation can be due to includes,decrease in intestinal motility (which can be heard by a stethoscope.)

It is not a cohort study.Its just a case study.Case study has low ability to proof anything.
I have posted only my findings,thats it.It does not proof anything,obviously it shows something...I want to point out that.

I do have permission from Respected Government of India,Ministry of Health,to carry out experiments on certain animals.I also have the permission to carry out experiments on Human being after receiving written consent from them.I do not cross any legal boundary,if it is done for the sake of well being of human beings.I dont want to go into details.

And for your kind information,actually there is no guideline for "conducting real research"...penicillin was not discovered in any controlled condition,Sir John Hunter did the things upon himself without any control,without any prior check up.
I dont consider my findings to be compared with these real Giants of medical innovations.
I dont have any interest to do a research work for e-cigs-I did the things for my own pleasure to quench my thirst.And I told you what I found,thats it.

What I did,I made my findings a open source by posting here.If any worker interested,he or she can proceed to against or for my findings.

Mind that,if I had any intension to proof e-cig is dangerous,I would not post a single line here,I have the ability to report to proper place.

what I want to say,e-cig is better than regular cigs,as it does not contain thousands of bad,known carcinogens.But,a thought should be given for its ill effects.

 

[idoesmoking]

Yes, that in itself gave me the proof I need to realize this guy is full of crap.... no pun intended. Notice he hasn't even made the attempt to explain what a few have posted for a response to question his supposed experiment. I certainly hope he washed his hands.........

Sorry for the fact,I was not able to post reply immediately.

I loved you called me crap... really.No satire intended.Yes,definitely you can oppose...but please dont come to conclusions so easily.

 

[JohnnyVapor]

idoesmoking, thank you for your study. However, I do have a couple questions(not to insult you, just wondering on your methodology).

Did you do a few tests without vaping for a few days to get a decent baseline? Were your results based on a single test or multiple tests to get an average?

Thank you for your time.

 

[idoesmoking]

idoesmoking, thank you for your study. However, I do have a couple questions(not to insult you, just wondering on your methodology).

Did you do a few tests without vaping for a few days to get a decent baseline? Were your results based on a single test or multiple tests to get an average?

Thank you for your time.

Jonny,why I will take it as an insult?

Look,I had no e-cig 1 month ago.I conducted the tests after vaping for 14 days and analog totally off. Blood tests were done taking three samples from three sites of my body at different time of the day.But,the test on rabbits were done only once...(as I have no intension to submit the records/test results).

Thank you very much to you as well.

 

[idoesmoking]

If I remember correctly, I read that somewhere rather authoritative. It may have even been in the tobacco company documents that were released to the public, but I'm not sure. Either way, PG/VG in a cig does vaporize as it's heated by the cherry, so some volume of exhaled cigarette smoke is almost certainly PG/VG vapor. Ever notice how cigarette smoke is unlike any smoke produced by other means? That's the result of constant BT product testing and tweaking - they know a big part of the experience is from the exhale of thick "clouds". Not surprising at all that they would maximize that as much as possible.

I also heard so.Forgot the reference.Also heard that,they dont mix VG/PG with the pouch tobaccos.Remember the "quality" of smoke is very different of a handmade cig?