The difference I have seen is the VW mod that can handle a low, super sub-ohm build, set at a high wattage, say above 80 watts is a serious kick in the lungs.
Examples -
Sigelei 150watt with your favorite RDA, coiled and wicked with your favorite wire and wick, at a guess for the example 24awg, 3mm Inner Diameter, 5/4 wrap, dual coil, kanthal a1, approx 0.2 to 0.3 ohms set at 70 watts
A simple single battery mech mod with same setup, Sony VTC series battery, should be outputting around 70 watts
In my experience, the Sigelei at those set variables above is sending a heck of a lot more power output than 70 watts, feels in the range of 100+ to me, the mech feels a little anemic in output compared to the VW mod. Reason being there are other variables not being calculated with the mech, voltage drop, conductivity of the mech mod materials, etc, the ending coil is not getting a full 4.2v, but closer to 3.9 or lower after those variables can be calculated into the equation. Still all in all, I do own mech, some authentic, some clones, and still like their simplicity, durability, and longevity, as well as ability to be quickly fixed. Yet on the other hand, I started with cigalikes, moved to Ego style, then into first gen VW units, got into rebuilding and mechs, now leaning back down the road of VW regulated mods, the mechs sitting idle mostly as building and testing platforms, the regulated mods my all day runners.
So it goes into preference of what you are wanting, comparing peaches to nectarines.