Studies suggest that smokers require less frequent repeated revascularization after percutaneous coronary intervention(PCI).[28] Risk of ulcerative colitis has been frequently shown to be reduced by smokers on a dose-dependent basis; the effect is eliminated if the individual stops smoking.[29][30] Smoking also appears to interfere with development of Kaposi's sarcoma in patients with HIV.[31]
Nicotine reduces the chance of preeclampsia,[32] and atopic disorders such as allergic asthma.[33][dubious – discuss] A plausible mechanism of action in these cases may be nicotine acting as an anti-inflammatory agent, and interfering with the inflammation-related disease process, as nicotine has vasoconstrictive effects.[34]
Tobacco smoke has been shown to contain compounds capable of inhibiting monoamine oxidase, which is responsible for the degradation of dopamine in the human brain. When dopamine is broken down by MAO-B, neurotoxic by-products are formed, possibly contributing to Parkinson's and Alzheimers disease.[35]
While tobacco smoking is associated with an increased risk of Alzheimer's disease,[36] there is evidence that nicotine itself has the potential to prevent and treat Alzheimer's disease.[37] Nicotine has been shown to delay the onset of Parkinson's disease in studies involving monkeys and humans.[38][39][40] A study has shown a protective effect of nicotine itself on neurons due to nicotine activation of α7-nAChR and the PI3K/Akt pathway which inhibits apoptosis-inducing factor release and mitochondrial translocation, cytochrome c release and caspase 3 activation.[41]
Studies have indicated that nicotine can be used to help adults suffering from autosomal dominant nocturnal frontal lobe epilepsy. The same areas that cause seizures in that form of epilepsy are responsible for processing nicotine in the brain.[42]