I have been using the nautilus Mini on my istick and due to the small size I do need to take it off and refill it often. Thankfully the threads on the Istick seem to be fine. Opening the nautilus Mini is another story, it seems to get tougher and tougher to open. I have to use rubber bands and gloves and it is always a huge pain. Just my 2 cents.
I am no expert but as far as my Nautilus Mini goes, I read somewhere where you can screw the base on just until it is snug, not to take it all the way tight. I have done this since I received mine and I haven't had any problems with flooding or leaking and it comes apart fairly easily. This may not be your issue. I just thought I would mention it as it has worked well for me.
Now as to having to refill it often, mine has this problem too! My juice just keeps vaporizing out the top!
I use the Silo Lite and Nautilus Mini tanks, which both have spring loaded firing pins, and my threads seem to be fine on my iStick as well. I switch between the tanks at least once a day.
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