Personally I'm terrified of placing a battery in upside down. Any tear in the battery's shrink wrap will result in a dead short as soon as you press the button. With the battery pointed up, you'll always have the atomizer to act as a load/fuse.
Also, In the u-can, I don't see how placing the battery upside down will buy you anything in terms of space... In fact it would take up more space. You'd need to use a thicker o-ring at the bottom to add clearance for button throw. Placing the battery upright doesn't cost anything because there is plenty of head room above the battery nipple. The deck cap is catching the battery on the shoulder of the battery, not the nipple.
Sorry... Not not trying to be an ...... Just thinking out loud...
On mine, I have a pretty thick oring at the bottom because the head of the screw I'm using is quite large...in my case larger than the nipple of the battery plus.
I didn't know that putting a bat plus down was considered dangerous.
L