I completely agree with the fact that HOW a person reacts to nicotine is just as personal as how we react to caffeine.
Case in point: me.
I cannot drink coffee without getting the jitters. I only drink hot tea or iced tea. But I can drink gallons of tea and have no effect other than not feeling like I want to crawl to the nearest cot and take a nap. With coffee, I feel nauseated, sweaty, and my heart races. Now my mom, she can chug coffee by the gallon with zero effects. But she cannot touch tea of any kind or SHE gets nauseated and feels dizzy. 2 types of caffeine, 2 people, 2 different reactions to the administration and type of caffeine.
Now take nicotine. When I smoked, by BP was 110/65. Now that I vape, it is 102/60. I am considered slightly hypotensive no matter HOW I get my nicotine. BUT.....I am also an active 36 year old, BMI of 20, normal weight, normal cholesterol, I do not consume alcohol more than a few times a year, and I have no significant family history of hypertension. Compare my stats to someone who is 40, overweight, sedentary, and pounds greasy cheeseburgers and fries all day. Plus drinks alcohol and their own weight in sugary drinks. AND has a BMI over 26. They quite possibly have hypertension. BUT.....is it due to nicotine? Can't really tell since they have every other risk factor for hypertension going for them as well. Add in a positive family history for HTN and ya know what? NICOTINE will be the ONE thing the dr picks out of the line up to bark at you about when he tells you to modify your lifestyle to reduce your high blood pressure. NICOTINE will be the one that gets the blame. Based on my medical experiences, I would hedge a bet that the nicotine is the LEAST of this hypothetical persons' worries. They should exercise, eat properly, lose weight, cut out the crap food and the crap drinks, and THEN evaluate their BP. Bet it went down whether or not they gave up nicotine.
When you look at the landscape of America, obesity and poor eating habits are THE biggest epidemic to future health complications such as morbid obesity, diabetes, heart disease, and hypertension. And I CAN back this statement up with loads of credible references. Our eating habits are going to be our demise if we don't find a way to turn the poor diet train around. More people are overweight and obese than aren't.
One more thing that I have mentioned a few times on here that bears reminding. It is easy to blame nicotine and vaping on EVERY poor health experience we get. Every day, I read "I have a sore throat/gas/indigestion/high cholesterol/high blood pressure/chest pain/cough/numbness/tingling/constipation/......../etc" and EVERY time the poster is trying to correlate it with vaping!! 9 times out of 10, it has NOTHING to do with vaping OR nicotine. So why does nicotine become the scape goat? Because we do NOT want to face the fact that most of us make poor health choices with EVERYTHING except our choice to quit smoking.
Annnnnndddd....stepping off soap box.