Elaine:
Below I have reprinted the entire discussion section of the TC letter. Can you please tell me where I said that ECIGs would be "unlikely to be helpful in quitting smoking"?
Tom E.
PS: A short report describing the current "experienced users" study has been revised to address reviewers' comments and is now under re-review...
"Relative to a tobacco cigarette, 10 puffs from
either of these electronic nicotine delivery
devices (E-cigarettes) with a 16 mg nicotine
cartridge delivered little to no nicotine and
suppressed craving less effectively (see Bullen
et al).6 Importantly, these results were from
two specific products tested under acute
conditions in which puff number was
controlled. Variability in product design may
influence vapour content7 and chronic use
and/or more intensive puffing (ie, more puffs,
greater puff volume) may influence nicotine
delivery. Given these and other factors, there
is an ongoing need to evaluate electronic
nicotine delivery devices (E-cigarettes). These
evaluations should be conducted in a manner
that takes into account variability in design
(including cartridge nicotine content),
examines the effects of user behaviour over
time and compares these products to existing
methods of delivering therapeutic nicotine
safely and effectively. Taken together, the
well known lethality of nicotine, variability
in cartridge/vapour content,7 and the
results reported here all support the notion
that electronic nicotine delivery devices (Ecigarettes)
and their nicotine-containing
solution should be evaluated, regulated,
labelled and packaged in a manner consistent
with cartridge content and product effect. At
the least, consumers should be aware that,
unlike several regulated nicotine products
(eg, gum,8 patch9), these putative drug
delivery systems do not delivery nicotine
effectively after acute administration."
They are trying to verify whether experienced users are getting nicotine from their e-cigarettes. It is unknown how Eissenberg plans to interpret the results they get.
Their first e-cig experiment involved novice users, measuring blood levels of nicotine after 10 puffs from an e-cigarette. Before all the data was gathered, Eissenberg sent a letter to the editor of Tobacco Control announcing that e-cigarettes do not deliver nicotine, and postulated that, because of this, e-cigarettes are unlikely to be helpful in quitting smoking.
Eissenberg reported preliminary results for this new study at the annual conference of the Society for Research on Nicotine and Tobacco. This was a brief report called a "poster" and the results involved only three subjects. There is a discussion elsewhere in ECF.
http://www.e-cigarette-forum.com/fo...nbergs-study-yep-e-cigs-deliver-nicotine.html