New studies find carcinogens in vg and pg at high temps, even in tootle puffers

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Katya

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Mazinny

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Yes, the vapor that reaches you mouth, and inhaled into your lungs is certainly cooler than the liquid in contact with the coil. It is the temperature at which it is being vaporized/aerosolized that will result in thermal breakdown, and that cannot be determined from the temperature of the vapor. It will be governed by the heat transfer from coil to liquid. As to the temperature on exhaling, well, by then the stuff has run through your respiratory system and no longer has real relation to the temperature back at the start of the process.



Huh. Went back and read that Nutt paper. I had never seen it before. It is certainly disappointing in its scientific rigor of establishing a risk strata for a variety of tobacco/nicotine products. It read as more a committee compromise presentation where the methods employed were reminiscent of behind closed door negotiations than direct experimental findings. I don't mind literature reviews. A proper literature review would tell me what finding from what study is being relied on to assign some value in the overall review. Unless I read the wrong Nutt paper, there wasn't all that much e cigarette literature used to establish "safety" (one by Saitta in 2014, and the other Farsalinos in 2014 as well). I'm assuming it's this one http://eprints.lse.ac.uk/56631/1/__lse.ac.uk_storage_LIBRARY_Secondary_libfile_shared_repository_Content_Phillips, L D_Estimating harms_Phillips _Estimating harms_2014.pdf and the criteria to establish risk stratification was more a checklist than pooled data (I guess that was done by the behind the closed door people). They were pretty proud of their MCDA program "1 An MCDA computer program first developed at the London School of Economics and Political Science and now available from Catalyze Ltd., www. catalyze.co.uk"
which tabulated their weighed scores (not sure how it's better than Excel, but whatever).

That little item does leave me wishing for more data like in that ANTZ Glasser presentation with pulmonary exacerbation improvement in COPD and lower nasties measured she presented. I'm really wishing for a device
dependent temp control study of aldehyde production at different board settings, with a comparison to that found by Wang in their device independent study. At least they told you how they generated their numbers.
You have the correct study. I found Phillips first blog on the study btw in case you are interested.

Please don’t cite the new Nutt et al. paper as evidence for tobacco harm reduction
 

David Wolf

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Oh, that statement was not in the context of relying on the temperature of the exiting vapor to determine the production of anything. It was in response to an issue raised about the exhaust temperature from the chamber was. from this quote "....what is the actual temperature of the liquid/vapor? I guarantee we aren't really inhaling 450 degree vapor."



We know they didn't test any e cig. We also know we don't vape the way that test was conducted. They stated that right up front in the study. What they did say was VG can break down to formaldehyde when heated to a temperature of 470F and higher (well a small bit below 470F but that seems to be the primary inflection point). There is nothing inaccurate in their finding that I could see that would make me doubt that result in the test setting applied.

The problem isn't that study. The problem is Evolv using that study to suggest by indirect means that the study supports the need for temp control or else. If Evolv used the chamber temperatures and reproduced the same release of aldehydes from actual tanks with actual coils powered by actual TC boards, there would some validity to their position. They did not do that. That test needs to be done. Anything else is pure speculation.

Dr. F's tweet is factually correct. It also stated by the authors this was not an e cig. However, that factual statement does not refute the results. The question remains does contemporary vape gear produce aldehydes at significant levels with higher temperature use that vapers might reach? If so, at what temps in vape gear, and are they the same as in this study? And if true, is temp control required to prevent that or are other strategies just as effective?
As flawed though they are by not ensuring dry hits are not encountered during e-cig testing, I put far more credence in studies on actual vaping devices than the study of VG in a heated tube test, which I totally discount as far as any direct relationship to vaping, and only of value to showing what temperatures VG and PG (NOT coils) start releasing significant amounts of aldehydes (which to me is still very valuable information, yet unfortunately information misconstrued throughout this thread as temperatures we must not let our COILS reach).
I've seen several studies showing generally much lower aldehydes in ecigs/vaping devices than in cigarettes (or the "tube test"). This study, though a bit dated, for example is decent in the fact that though it shows a very high amount of aldehydes in a CE4 obviously misused to the point it damaged the coil, did indeed point out that damage. And it also showed significantly lower aldehydes than cigarette smoke for a Nautilus and a Subtank, even at higher power levels:
Effect of variable power levels on the yield of total aerosol mass and formation of aldehydes in e-cigarette aerosols
Of particular interest is Section 4 Discussion, which states in part:
"As shown in Table 4, formaldehyde yields for Device 1 exceeded both the yield from combustible cigarettes (20 per day) and the OSHA limit even at the lowest power level and, at the maximum power level, produced formaldehyde almost 10 times the OSHA workplace exposure limit. This device also exceeded the acrolein yield from 20 combustible cigarettes per day and the OSHA workplace exposure limit, but only at the highest power level tested. Device 2 also exceeded the formaldehyde yield from combustible cigarettes but again only at the highest power level tested. In contrast, the other three devices all produced aldehydes below both combustible cigarettes and the OSHA workplace exposure limit. One device, Device 5, produced less than 1% of the aldehydes delivered from 20 combustible cigarettes per day and the OSHA workplace exposure limit. Also, there was over a 750-fold difference in total aldehyde yield between Devices 1 and 5. The extreme levels of aldehydes produced by Device 1 indicate that the coil may have overheated due to lack of liquid in the wick. In this case, the excess energy would be transformed into heat and the coil temperature would exceed the evaporation point of the e-liquid (22), with heat-induced decomposition processes competing with aerosolization. At the conclusion of this study, the coil for Device 1 was examined and found to be charred, an indication of thermal decomposition. The charred coil, the observed decrease in yield in mg/watt production at the highest power level, and the elevated levels of aldehydes and acrolein, all indicate that the results for Device 1 may not represent typical usage of this device, we hypothesize, and a typical user might experience noxious dry-puff effects and discontinue use at that power setting. However, determination of dry-puffs is outside of the scope of this study since dry-puffs can only be confirmed by sensory evaluation of the aerosol by a user (Farsalinos et al., 2015)."

I would love to see studies using TC control devices, verified by testing to be accurate at the temperature setting used in the test, vaping pure VG, pure PG, at 400 deg F, 450 deg F, 500 deg F, 550 deg F, using cotton wicks, and also verified by real vapers to not be providing dry hits at those temperatures. So lets see aldehyde levels at known COIL temperatures. My predictions using common sense knowledge of the cooling effects of vaporization, the fact that the PG or VG in the wick is NOT at the coil temperature except at the points of molecular contact, are that we will see far lower (but not insignificant at higher temperatures) aldehyde levels than that produced at the tube test temperatures. And the results will therefore mirror the more applicable testing done with actual vaping devices than the tube test, which after all, was not a vaping coil temperature results test, but a test of the aldehyde release of VG and PG temperature.
Oh, one closing note, who the heck ever took 5 second draws off of a CE4. No one ever I knew of :D
 
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vapdivrr

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Echo those sentiments vap as @super_X_drifter's persistence with closed winds once he arrived there and your video efforts with annealing to stabilize form were instrumental to my appreciating the potential of this technology, provided me with enough certainty to quit and contribute here. Thank you both.

Good luck. :)
Hey buddy! And help you have. Always love your threads and posts , very informative. ..

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vapdivrr

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Ahh, yes, the good ol' daze. That's way back when eliquid vendors were catering to the smoker (vaper to be) rather than the vaper.



You're a TPuffer, vapdivrr. ;) I don't know if it'll make a (huge) come back, but I do know for me it's never left.
I often wonder if I'm a tootle puffer, I obviously have heard that term , but don't think I am (I don't care if I am, if I am) . I do vape sort of low wattages, mid 20's, but also vape most of my rta's in the .7 range and at 24mg nic, my vape produces major TH, so much I'm pretty sure that it would choke 70 percent of the vapors here. So I maybe a TP, but I think I'm more of a tootle subber.[emoji3]

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Katdarling

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but I think I'm more of a tootle subber.
emoji3.png

Tootle Subber. Like that!
 

GeorgeS

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    DJLSBVapes does a decent job testing the accuracy of the TC mods he reviews. Many of us dedicated TC users have done plenty of cotton singe and water boil tests testing the TC vaping gear we use.

    Bottom line: I believe the temperature of the coil on most high end TC devices is within +/- 5F of the temperature set.

    So in an atomizer there ought to be only ONE heat source - that being the coil itself. Unless there is some amount of pressure (enough to raise the temperature of the liquid) OR there is some far more scary chemical reaction going on inside the atomizer when the coil is firing:

    Bottom line: I believe that the liquid in the atomizer is limited to the temperature of the heat source (coil) and can't go above the temperature of the coil itself.

    So a study comes out which offered a device independent study of temperature and possible toxic gasses which can be emitted when the various liquids were heated to various temperatures.

    Bottom line: Taking the above into consideration I believe that if the coil temperature never equals the temperature which toxic gasses are shown to be created the toxic gasses will not happen.
     

    Eskie

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    As flawed though they are by not ensuring dry hits are not encountered during e-cig testing, I put far more credence in studies on actual vaping devices than the study of VG in a heated tube test, which I totally discount as far as any direct relationship to vaping, and only of value to showing what temperatures VG and PG (NOT coils) start releasing significant amounts of aldehydes (which to me is still very valuable information, yet unfortunately information misconstrued throughout this thread as temperatures we must not let our COILS reach)......

    .....I would love to see studies using TC control devices, verified by testing to be accurate at the temperature setting used in the test, vaping pure VG, pure PG, at 400 deg F, 450 deg F, 500 deg F, 550 deg F, using cotton wicks, and also verified by real vapers to not be providing dry hits at those temperatures. So lets see aldehyde levels at known COIL temperatures.

    Agreed. Having some independent determination of the temperatures likely to result in thermal degradation is quite useful. That it will be misrepresented does suck, but is particularly galling when it's a vape company that's first up to misinterpret and imply their hardware would prevent it.

    You are also correct, the next step is let's see this in a tank with a temp controlled coil at varying temperatures and the amount of aldehydes measurable. Sorry I sorta edited out your expectation, which I happen to agree with, that it will likely be lower than the chamber test, but it was sorta the only way I could get all the important stuff to show in your quote. These fading quotes setup isn't always helpful if you're trying to address different points in a longer post.

    Edit: didn't help anyway, the bottom is still cut off
     

    David Wolf

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    Agreed. Having some independent determination of the temperatures likely to result in thermal degradation is quite useful. That it will be misrepresented does suck, but is particularly galling when it's a vape company that's first up to misinterpret and imply their hardware would prevent it.

    You are also correct, the next step is let's see this in a tank with a temp controlled coil at varying temperatures and the amount of aldehydes measurable. Sorry I sorta edited out your expectation, which I happen to agree with, that it will likely be lower than the chamber test, but it was sorta the only way I could get all the important stuff to show in your quote. These fading quotes setup isn't always helpful if you're trying to address different points in a longer post.

    Edit: didn't help anyway, the bottom is still cut off
    yeah well I put up a long winded post, hard to deal with those, haha :D
     
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    David Wolf

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    (sigh)

    DJLSBVapes does a decent job testing the accuracy of the TC mods he reviews. Many of us dedicated TC users have done plenty of cotton singe and water boil tests testing the TC vaping gear we use.

    Bottom line: I believe the temperature of the coil on most high end TC devices is within +/- 5F of the temperature set.

    So in an atomizer there ought to be only ONE heat source - that being the coil itself. Unless there is some amount of pressure (enough to raise the temperature of the liquid) OR there is some far more scary chemical reaction going on inside the atomizer when the coil is firing:

    Bottom line: I believe that the liquid in the atomizer is limited to the temperature of the heat source (coil) and can't go above the temperature of the coil itself.

    So a study comes out which offered a device independent study of temperature and possible toxic gasses which can be emitted when the various liquids were heated to various temperatures.

    Bottom line: Taking the above into consideration I believe that if the coil temperature never equals the temperature which toxic gasses are shown to be created the toxic gasses will not happen.
    Well I respect your right to believe anything you wish, but I find it interesting you quote DJLsb Vapes and then state you believe "the temperature of the coil on most high end TC devices is within +/- 5F of the temperature set." When his reviews totally demonstrate the opposite of that (I linked several of his reviews). Did you mean +/- 50F? That I might believe, because no way on earth anyone has the technology to make THAT accuracy across the span of temperature control, especially when even the wire you buy isn't always on the money for it's TCR. You might find one point where it crosses that accuracy point, like 400 deg F that most manufacturers try to cross, lol :D NiFe wire has a large TCR, so you can get better accuracy with that (but not 5 deg F accuracy across the spread), but if you're using SS, show me a spread from 350 to 550 that's +/- 5 deg F, and you will have yourself a new best selling TC mod :D :D :D
     
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    GeorgeS

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    Well I respect your right to believe anything you wish, but I find it interesting you quote DJLsb Vapes and then state you believe "the temperature of the coil on most high end TC devices is within +/- 5F of the temperature set." When his reviews totally demonstrate the opposite of that (I linked several of his reviews). Did you mean +/- 50F? That I might believe, because no way on earth anyone has the technology to make THAT accuracy across the span of temperature control, especially when even the wire you buy isn't always on the money for it's TCR. You might find one point where it accidentally crosses that accuracy point, lol :D

    The devices you quoted and referenced are not "high end" nor are their TC at all functional. (I even tossed in a disclaimer of "most")

    I own a number of Sxmini's, DNA75's, Dicodes and others that can reliably regulate to +/- 5F of the set temperature. I've done both cotton singe and water boil tests on most my high end mods and are quite happy with my test results. (which reinforce the results that reviewers that test the temperature accuracy get)

    That is not to say that there are not devices on the market that CLAIM they can do TC but can't. DJLsb has exposed a number of them.

    Just because SOME TC devices can't accurately regulate coil temperature does not mean that ALL TC devices can't.
     

    englishmick

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    we do know the simplest part of the equation....what we don't know, is the theoretical side, that would answer the question of heat our liquids reach during atomizing. My best guess would be no, they don't reach temps beyond their boiling point in most cases. Inhaling anything that was truly at the temps listed in this study would be beyond unpleasant, and harmful. Put your hand in 400 degree water....what happens? Ever had a steam burn, from say a radiator? That is a closed system, where it is very easy for the liquid to reach beyond its boiling point.......which also creates high pressure, something else we DON'T see in our gear. At minimum, we would be blistering our mouths and throats if our vapor was truly reaching such temps.

    On the subject of temperature and pressure, I had a thought. Tanks aren't closed systems. As we are sucking on the drip tip we are reducing the pressure inside the tank. Maybe not so much on a subohm tank with huge air holes, but I reckon the pressure over the coil in my Kayfun gets quite a lot lower while I'm drawing on it. That should reduce the boiling temp of the juice.

    Don't know how much the pressure is reduced or how much that would change the boiling temp of VG or PG. But if it is significant that might even explain why you can get vapor well below the normal boiling temp.

    Now we need a volunteer to do pressure measurements inside a Kayfun. :sneaky:
     

    MacTechVpr

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    Don't know how much the pressure is reduced or how much that would change the boiling temp of VG or PG. But if it is significant that might even explain why you can get vapor well below the normal boiling temp.

    :thumb: More than most realize, VG, mebe?

    Good luck. :)
     
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    David Wolf

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    The devices you quoted and referenced are not "high end" nor are their TC at all functional. (I even tossed in a disclaimer of "most")

    I own a number of Sxmini's, DNA75's, Dicodes and others that can reliably regulate to +/- 5F of the set temperature. I've done both cotton singe and water boil tests on most my high end mods and are quite happy with my test results. (which reinforce the results that reviewers that test the temperature accuracy get)

    That is not to say that there are not devices on the market that CLAIM they can do TC but can't. DJLsb has exposed a number of them.

    Just because SOME TC devices can't accurately regulate coil temperature does not mean that ALL TC devices can't.
    I will ask you for the proof you have that your devices reliably regulate to +/- 5 deg F - have you verified this yourself? Or are you relying on a DJLsb review? Link it, I've looked at the most accurate TC device reviews he has and have seen several devices that have pretty good accuracy around 400-450 deg F there, but not across a range of 350 to 550. I haven't seen what test equipment he uses, nor do I know the accuracy of that equipment. The wire you are using alone can have variability in its actual TCR that will blow your +/-5 deg F error. I often work with test equipment using thermocouples that's calibrated, and a tolerance that tight across a range of 350 to 550 is excellent, we could use your TC mod as calibrated test equipment lol :D Do you use steam engine values, or does the manufacturer of your wire provide their specific TCRs you use? DKLsb labs shows differences in temperatures depending on what source you use. Basically anyone who claims they have TC that controls say SS 316L across a range of 350 to 550 to +/- 5 degrees, if they take their mod and atty with SS coil to a lab with precision calibrated equipment, will have a BS flag the size of Nebraska thrown at them :D By the way, the typical error of a Type J thermocouple (Iron / Constantan) -40 to 760 °C range, that you might use to test a coil temperature, is +/- 2.2 °C (~4°F). Pretty sure you're coil and TC mods not gonna be as good as a thermocouple :D
     
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    Lessifer

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    Yes, the vapor that reaches you mouth, and inhaled into your lungs is certainly cooler than the liquid in contact with the coil. It is the temperature at which it is being vaporized/aerosolized that will result in thermal breakdown, and that cannot be determined from the temperature of the vapor. It will be governed by the heat transfer from coil to liquid. As to the temperature on exhaling, well, by then the stuff has run through your respiratory system and no longer has real relation to the temperature back at the start of the process.



    Huh. Went back and read that Nutt paper. I had never seen it before. It is certainly disappointing in its scientific rigor of establishing a risk strata for a variety of tobacco/nicotine products. It read as more a committee compromise presentation where the methods employed were reminiscent of behind closed door negotiations than direct experimental findings. I don't mind literature reviews. A proper literature review would tell me what finding from what study is being relied on to assign some value in the overall review. Unless I read the wrong Nutt paper, there wasn't all that much e cigarette literature used to establish "safety" (one by Saitta in 2014, and the other Farsalinos in 2014 as well). I'm assuming it's this one http://eprints.lse.ac.uk/56631/1/__lse.ac.uk_storage_LIBRARY_Secondary_libfile_shared_repository_Content_Phillips, L D_Estimating harms_Phillips _Estimating harms_2014.pdf and the criteria to establish risk stratification was more a checklist than pooled data (I guess that was done by the behind the closed door people). They were pretty proud of their MCDA program "1 An MCDA computer program first developed at the London School of Economics and Political Science and now available from Catalyze Ltd., www. catalyze.co.uk"
    which tabulated their weighed scores (not sure how it's better than Excel, but whatever).

    That little item does leave me wishing for more data like in that ANTZ Glasser presentation with pulmonary exacerbation improvement in COPD and lower nasties measured she presented. I'm really wishing for a device
    dependent temp control study of aldehyde production at different board settings, with a comparison to that found by Wang in their device independent study. At least they told you how they generated their numbers.
    The RCP report is a bit like our surgeon general's report, more press release than scientific paper. The report was based on the PHE literature review which included the Nutt paper but also reviewed much more literature.

    The funny thing is, I'm pretty sure that if they actually went by the measured compounds in the studies that measured compounds in reference to smoking, the 95% would be more like 99%.

    I often wonder if I'm a tootle puffer, I obviously have heard that term , but don't think I am (I don't care if I am, if I am) . I do vape sort of low wattages, mid 20's, but also vape most of my rta's in the .7 range and at 24mg nic, my vape produces major TH, so much I'm pretty sure that it would choke 70 percent of the vapors here. So I maybe a TP, but I think I'm more of a tootle subber.[emoji3]

    Sent from my SCH-I545 using Tapatalk
    You're a modwomper.
     

    Katya

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    The RCP report is a bit like our surgeon general's report, more press release than scientific paper.

    True. But may I remind you that it was the 1964 Surgeon General Dr. Luther Terry's landmark "press release" about the dangers of tobacco use that led to a sea change in the world's attitude toward smoking? Let's hope that the RCP report has the same effect. :nun:

    You're a modwomper.

    Classic modwomper. :D
     

    Lessifer

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    True. But may I remind you that it was the 1964 Surgeon General Dr. Luther Terry's landmark "press release" about the dangers of tobacco use that led to a sea change in the world's attitude toward smoking? Let's hope that the RCP report has the same effect. :nun:



    Classic modwomper. :D
    Yup, also remember that the RCP released a report on Smoking and Health with much the same conclusions in 1962 Smoking and health (1962)
     
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