Vaping for nicotine advantages?

[birdy68]

Anecdotal only.. My experience. My husband is 4 years younger then I am. He has never smoked. I smoked heavily for 40 years and vape now. He has far more "Senior Moments" than I do. I have practically zero. He now looks to me for the answers to questions that he can't remember right off. He doesn't have Alzheimer's or anything. He just isn't as quick as I am, poor thing.
Well done, nicotine!

 

[Tundrax]

This open my eyes to different things. Do nicotine has the same effect as caffeine. As in making yourself awake?

 

[DC2]

I'm glad this was bumped...

It should definitely be bumped now and then.

 

[mosspa]

Try Dropbox. If you have a Samsung phone that is relatively new you can get up to 50gb of data. Without and just signing up I think its 2GB of room which is plenty. Put your artice into a folder and then you can make that folder public. Post the link here and that should solve that part. As far as your test and questions your trying to answer. My neurologist told me the receptors in the brain that picks up the nicotine are multifunctional and serve the need at hand. People who are stressed smoked to calm down. It can act as a stimulant to wake you up thus the quintessential Smokers morning cup of coffee and cigarette before anything else. At the same time is can act as a relaxant for sleep. That's as far as he went and I was a IT geek so the only thing I can add is I hope I read it wrong when you said your ordered 48MG starter kit and not cutting it down. 48MG is way to high to smoke. It can cause its own issue's For instance the 2 highest level of nicotine cigarettes are Camel(my old enemy) and cool. They were 3.3 or also know as 33mg. Even though Vapers typically get 10 to 40 percent it is highly warned against buy sellers of nicotine to go above 32mg some say 24. I to would love to read your final report

Research suggests that it takes about 45 mg/ml nicotine ejuice to get an equivalent blood borne nicotine concentration of a typical non-light cigarette. I have been vaping between 45 and 48mg/ml since I started (about 7 months ago) because most of the reported cognitive benefits of nicotine were derived from smokers. Sellers will always be in CYA mode. Locally, we have a vape shop that requires a signed release for making concentrations above 24 mg/ml. The staff there is always amazed when I ask for 45 mg/ml.

 

[mosspa]

This open my eyes to different things. Do nicotine has the same effect as caffeine. As in making yourself awake?

Nicotine is a stimulant, but not a sleep inhibitor. I'm an insomniac and I vape 8 to 12 puffs of 45 mg/ml ejuice about 30 min before I go to sleep. The nicotine hasn't interfered with my sleep, what so ever.

 

[mosspa]

I'm glad this was bumped...

It should definitely be bumped now and then.

I'm sorry I have been away for so long. Last semester was long and politically complicated, and I just didn't have too much time available for things like forum posting. Frankly, I'm surprised that this thread is still active Anyway, although I reported some of this in another thread last night, I probably bring readers of this thread up to date.

Migraines. I was at a little over 6 months (Nov - Jun) without a migraine. I stopped vaping on Jun 2. I had a migraine on Jun 10. Of course this could be coincidental, but when I start vaping for the fall semester (Aug 16) I'll keep note of it.

Withdrawal. I vaped consistently for the whole spring semester (Jan - April) (it was 17 weeks, total). On Jun 2, I stopped vaping coincidental with my attending a Behavioral Neuroscience conference in Victoria, CA. I never missed vaping, at all. I had no cravings or other symptoms. It will be interesting to see how tolerant I am to nicotine when I start up in a couple weeks.

Cognitive Improvement. For the spring semester I remained about where I was for the fall. I averaged about 68% fewer senior moments compared to baseline for four university classes.

My Wife's Sinusitis. The PG 'therapy' worked well. As was recommended here, she added Flonase sometime in April. She has been, pretty much, sinus symptom free since then.

In a nutshell, that is my latest data. Looking forward to starting vaping again.

 

[Tundrax]

Nicotine is a stimulant, but not a sleep inhibitor. I'm an insomniac and I vape 8 to 12 puffs of 45 mg/ml ejuice about 30 min before I go to sleep. The nicotine hasn't interfered with my sleep, what so ever.

I have searched on articles about caffeine and nicotine. It came out that both of them are stimulant which makes it hard to fall asleep. So, I guess that it really has an impact unless I am missing something out.

 

[LilZ]

Research suggests that it takes about 45 mg/ml nicotine ejuice to get an equivalent blood borne nicotine concentration of a typical non-light cigarette. I have been vaping between 45 and 48mg/ml since I started (about 7 months ago) because most of the reported cognitive benefits of nicotine were derived from smokers. Sellers will always be in CYA mode. Locally, we have a vape shop that requires a signed release for making concentrations above 24 mg/ml. The staff there is always amazed when I ask for 45 mg/ml.

Your quoting me based on research ???

Unless you have a Masters Doctorates in one of a couple of different medical fields, do not copy me in your post especially to tell me I'm wrong. I have multiple PEOPLE NOT RESEARCH from Google or wherever for my info. Coming on here and telling people is fine to vape that high of nicotine is not only careless but idiotic. Just because of have some ....ing vape shop does not make you certified on nicotine and how it affects the body. Someone with even an associates degree would not make that broad and stupid of a comment. The reason is different people handle various chemicals in various ways. For example, how many different OTC pain pills are there, any idea skippy. Like I said leave me out of your asinine post!

 

[DC2]

Oh, look, Battle of the Scientists is looming!


Someone might have wanted to read the first post in the thread.
But if this gets interesting, it should be very informative.

 

[Alien Traveler]

Research suggests that it takes about 45 mg/ml nicotine ejuice to get an equivalent blood borne nicotine concentration of a typical non-light cigarette. I have been vaping between 45 and 48mg/ml since I started (about 7 months ago) because most of the reported cognitive benefits of nicotine were derived from smokers. Sellers will always be in CYA mode. Locally, we have a vape shop that requires a signed release for making concentrations above 24 mg/ml. The staff there is always amazed when I ask for 45 mg/ml.

1. You are very wrong here. You can exceed nic level of smoker with any type of juice (even 3 mg).
2. Your advises are at best wrong and mostly dangerous.

 

[mosspa]

I have searched on articles about caffeine and nicotine. It came out that both of them are stimulant which makes it hard to fall asleep. So, I guess that it really has an impact unless I am missing something out.

Caffeine and nicotine are different in their actions as stimulants. Caffeine is a non selective methyl xanthine phosphodiesterase inhibitor that serves to increase intracellular cAMP (a second messenger). When cAMP is elevated, cells become more excitable. There are two primary second messenger molecules, cAMP and cGMP. cAMP is more prevalent in neurons that lead to behavioral (and brain) excitation (dopamine, norepinepherine, epinephrine, etc), although it is also found in monoamine neurons that are associated with behavioral depression and sleep (e.g., serotonin). So, the stimulant action one sees from caffeine is largely due to hyper-excitation in the excitatory neurons neurons. The reason caffeine causes sleeplessness is because it is acting on the same systems affected by amphetamine and ......., except with a much lesser overall effect.

Nicotine is a nicotinic acetylcholine agonist. That is, it acts directly on acetylcholine nicotinic receptors where it mimics the effects of acetylcholine. The preponderance of nicotinic receptors are contained in the peripheral nervous system. It is nicotinic stimulation that causes contraction of striate muscles that allow for body movement. The nicotinic receptors on the blood vessels cause constriction. In the brain, nicotinic cholinergic receptors are involved in learning and memory, concentration, and many other processes. The stimulant effects one sees from nicotine is largely due to its net effect on brain systems. It is not a behavioral stimulant the way caffeine is. In fact, nicotine has both activating and sedating properties, but the activation is much less behavioral in nature. The reason that it doesn't interfere with sleep is because of that.

I didn't intend to make this a pharmacology lesson.

PS: The dots after 'amphetamine' represent that stimulant compound that is often taken by nose.

 

[mosspa]

Your quoting me based on research ???

Unless you have a Masters Doctorates in one of a couple of different medical fields, do not copy me in your post especially to tell me I'm wrong. I have multiple PEOPLE NOT RESEARCH from Google or wherever for my info. Coming on here and telling people is fine to vape that high of nicotine is not only careless but idiotic. Just because of have some ....ing vape shop does not make you certified on nicotine and how it affects the body. Someone with even an associates degree would not make that broad and stupid of a comment. The reason is different people handle various chemicals in various ways. For example, how many different OTC pain pills are there, any idea skippy. Like I said leave me out of your asinine post!

Did I quote you? Well, I guess I did. This is a thread I started, after all. If you don't want to see what I am saying then, simply, don't read this thread (which you obviously haven't from the beginning, otherwise you would have answered your own questions). If you don't want to be quoted, please don't post here. For the record, I have a Ph.D. in psychopharmacology, with later post-doctoral training in neuropharmacology, neurophysiology, and neurotoxicology. I have taught pharmacology in two medical schools, and was the director of one of the largest US government neurotoxicology laboratories for over 12 years. So, does that meet your requirements?

The research I have cited in this thread is quality research published in peer-reviewed journals, not from Google. I hate to break it to you, but it is fine for most people (i.e., those who are not cardiovascularly challenged) to vape 45 mg/ml of nicotine (using second generation cartomizers). I assume you were/are a smoker, so you might be interested in knowing that on a puff for puff basis, it takes about 45 mg/ml nicotine concentration in ejuice (using EVOD-type cartomizers) to achieve the same blood dose of nicotine provided by a drag on a standard non-light cigarette. So, in that EVOD-type situation (it was a second-generation EVOD-type device used in the research I have cited, and I use SmokTech equivalent for my personal vaping) it should be obvious that 45 mg/ml nicotine concentration is far from dangerous.

Before going postal, please go back and read this thread from the beginning. You might actually learn something.

 

[theddead]

I'm a university professor (neuroscience), and in many of my classes I have extolled the virtues of nicotine when divorced from smoke. Having followed the vaping forums for several years, and watching various websites for adverse effects, I have finally decided to take my own advice and begin vaping to reap the benefits of nicotine. I am 59 years old and haven't smoked a cigarette since April 12, 1972 (after smoking from 7th grade and throughout high school). Many of my friends think I'm nuts, but they can't really dispute the science that strongly suggests that nicotine, especially in older individuals, improves cognitive performance, reduces the probability of Alzheimer's onset, improves memory (especially in reducing those 'senior moments' when you can't get the word out you are looking for), and reduces 'time to sleep' at bedtime. I'm in good shape, physically, and except for a small; increase in heart rate and blood pressure immediately after vaping, the effects are transient (last about 45 min - 1 hr), and don't seem to be detrimental. I vape 5-8 drags about 4 times a day, and I generally don't vape before noon, so I'm probably clearing most of the nicotine (assuming a 2-3 hr half life) daily.

I have been vaping for about a month and I have observed some phenomenological effects that I didn't anticipate, the most dramatic of which is the increase in ethanol-induced euphoria (alcohol buzz) after a few drinks. When I quit smoking 40-some years ago, I did so without any withdrawal symptoms, but I think quitting (I was smoking almost 2 packs a day at the time) was easy because there didn't seem to be much reason to smoke (i.e., I don't think I ever observed euphoria strengthening back then, but in retrospect, with my cigarette usage being so high at the time, I was probably nicotine saturated so the contrast effect, may not have been apparent).

This past month, I have recorded how many "senior moments" I had in my lectures, and in casual conversation, and they averaged about 1.8/day. This coming semester I intend to vape before each lecture and compare my memory lapses when nicotine stimulated to what I observed this past semester. I know this is not a real experiment, but I think it will be interesting even if I even experience a placebo effect.

Anyway, does anybody else here vape for similar reasons?

I won't go into my personal issues but I will say that I notice when I "run low" on nic in my body.
And I do find it helps me.
I have no plans to quit vaping as I find out to be my perfect little self medicator.

 

[mosspa]

1. You are very wrong here. You can exceed nic level of smoker with any type of juice (even 3 mg).
2. Your advises are at best wrong and mostly dangerous.

No, you are wrong and you have no way to support your argument with real data. What the research suggests is that on a PUFF FOR PUFF basis, using second-generation EVOD-type equipment, it takes about 45 mg/ml nicotine concentration to achieve the same blood dose of nicotine provided by a standard non-light cigarette. Of course you can chain vape 3 mg/ml an achieve very high blood concentrations. Since you obviously have entirely missed the whole point of this thread, I have no interest on sucking low-dose vapors for extended periods of time, because I am using nicotine for its cognitive benefits (and I believe I have been very successful), not because I am trying to get off cigarettes. Also, much of the initial research was of of an epidemiological nature, and the 'subjects' were cigarette smokers. So, I concluded that 45 mg/ml was a good starting point. I vape, just like I used to smoke (except much less frequently, and mostly only during the school day. I take about 8-11 drags from my SmokTech unit about 12 times a day, and again at night before I go to sleep. There is nothing dangerous about this, at all.

 

[SlickWilly]

Research suggests that it takes about 45 mg/ml nicotine ejuice to get an equivalent blood borne nicotine concentration of a typical non-light cigarette. I have been vaping between 45 and 48mg/ml since I started (about 7 months ago) because most of the reported cognitive benefits of nicotine were derived from smokers. Sellers will always be in CYA mode. Locally, we have a vape shop that requires a signed release for making concentrations above 24 mg/ml. The staff there is always amazed when I ask for 45 mg/ml.

I'd urge you to do more research, I was a heavy smoker for 40 years and 24mg had my head spinning! That percentage of nicotine sounds very dangerous to me. High levels of nicotine can kill you, that's why it has POISON on the label!

 

[DC2]

I'd urge you to do more research, I was a heavy smoker for 40 years and 24mg had my head spinning! That percentage of nicotine sounds very dangerous to me. High levels of nicotine can kill you, that's why it has POISON on the label!

NJoy sells some of their products in that range of nicotine.
So do some of the other cigalike brands.

That's because they believe it needs to deliver, and is not dangerous.

I don't see any lawsuits against them yet.
Nor do I ever expect to.

I'll also just go ahead and throw this out there...
Don't let anyone tell you that nicotine is a poison... | E-Cigarette Forum

FUD is not good.

 

[mosspa]

I'd urge you to do more research, I was a heavy smoker for 40 years and 24mg had my head spinning! That percentage of nicotine sounds very dangerous to me. High levels of nicotine can kill you, that's why it has POISON on the label!

24 mg/ml using what type of equipment? I use a SmokTech glass cartomizer, and I've been vaping 45 mg/ml for about 8 months. Yes, at first I got a bit dizzy, but not puking dizzy the way I did when I smoked my first cigarette some 48 years ago. Yes, nicotine is a toxicant and it is possible to kill one's self with it. However, it takes about 20 times more than most textbooks and the government (CDC) warn about. This is all nicely reviewed in an Archives of Toxicology article from 2014, entitled "How much nicotine kills a human: Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century". Here's the link How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century

One cigarette yields about 2mg of nicotine or a blood concentration of about 30 ng/ml. The paper I cited much earlier in this thread suggests that using EVOD-type equipment it takes about 8 drags of 45 mg/ml concentration nicotine to achieve this same blood level. Far from dangerous, me thinks.

 

[Topwater Elvis]

For the record, I have a Ph.D. in psychopharmacology, with later post-doctoral training in neuropharmacology, neurophysiology, and neurotoxicology. I have taught pharmacology in two medical schools, and was the director of one of the largest US government neurotoxicology laboratories for over 12 years. So, does that meet your requirements?

The research I have cited in this thread is quality research published in peer-reviewed journals, not from Google. I hate to break it to you, but it is fine for most people (i.e., those who are not cardiovascularly challenged) to vape 45 mg/ml of nicotine (using second generation cartomizers). I assume you were/are a smoker, so you might be interested in knowing that on a puff for puff basis, it takes about 45 mg/ml nicotine concentration in ejuice (using EVOD-type cartomizers) to achieve the same blood dose of nicotine provided by a drag on a standard non-light cigarette. So, in that EVOD-type situation (it was a second-generation EVOD-type device used in the research I have cited, and I use SmokTech equivalent for my personal vaping) it should be obvious that 45 mg/ml nicotine concentration is far from dangerous.

Before going postal, please go back and read this thread from the beginning. You might actually learn something.

I'd be interested in reading this peer reviewed research, lets see a copy of your credentials since you threw them out there.
Do you understand what you say seems ridiculous to many here?
To say that a non nicotine user can / should or it would be safe for them to pick up, start or even vape on 45mg/ml is ludicrous. And very easily could be dangerous to anyone.

What if they didn't understand or missed the part about 2 gen evod / smoktech equivalent?
Do you not understand that many start off with substantially more efficient delivery systems?

When I vape 3 puffs of 12 mg/ml my ears ring, 3 more headache, 3 more heart races sweat forms, 3 more sweat profusely, 3 more stomach distress & other obvious signs of nicotine OD occur.
Why? because Ive reduced down from 36mg/ml to 6mg/ml over a period of years.
I was a 2 -3 pack per day smoker.

I really don't understand how you can take 88 - 132 vapes of 45mg/ml per day and not feel
some serious side effects.

A doctors recommendation that a new vaper or non smoker can start vaping at 45mg/ml nic and it is fine for most people,,, seems legit.
Sounds more like advice from an interweb dr or a trojan horse.

 

[Alien Traveler]

I'd be interested in reading this peer reviewed research, lets see a copy of your credentials since you threw them out there.
Do you understand what you say seems ridiculous to many here?
To say that a non nicotine user can / should or it would be safe for them to pick up, start or even vape on 45mg/ml is ludicrous. And very easily could be dangerous to anyone.

What if they didn't understand or missed the part about 2 gen evod / smoktech equivalent?
Do you not understand that many start off with substantially more efficient delivery systems?

When I vape 3 puffs of 12 mg/ml my ears ring, 3 more headache, 3 more heart races sweat forms, 3 more sweat profusely, 3 stomach distress & other obvious signs of nicotine OD occur.
Why? because Ive reduced down from 36mg/ml mg to 6mg/ml over a period of years.

I really don't understand how you can take 88 - 132 vapes of 45mg/ml per day and not feel
some serious side effects.

A doctors recommendation that a new vaper or non smoker can start vaping at 45mg/ml nic and it is fine for most people,,, seems legit.
Sound more like advice from an interweb dr or a trojan horse.

Exactly ^^^

 

[DC2]

What if they didn't understand or missed the part about 2 gen evod / smoktech equivalent?
Do you not understand that many start off with substantially more efficient delivery systems?

This is an important consideration.
A VERY important one.