Vaping for nicotine advantages?

[mosspa]

Just one thing to note... the nicotine content has nothing to do with nicotine intake. An evod setup running at 3.3V might deliver less nicotine than my Sigeli 100 @ 6mg/ml. Instead of the person saying he takes X amount of vapes of X amount of concentration, he should note how many milliliters of what dosage of ejuice has been vaped to get a more accurate measure. If he consumed 1ml of 48mg juice during those 100 vapes, then he's getting about a pack per day intake. If he consumed 10 ml of 48mg juice during those 100 vapes, then yes, he is doing some serious overdosing.

If you look back in this thread, I have done that. When I started about 8 months ago (I mean, at the end of the first 2 months), I was doing about 0.5 ml of 45-48 mg/ml juice. For the last several months of my most recent run I was doing about 1.0-1.6 ml. I understand that all of this is equipment dependent and that when one factors in dripping, all bets are off. However, the last paper that I found that did a serious analysis of blood chemistry used similar equipment to what i have been using (I'm currently using an EVOD-like SmokTech Glass cartomizer, and when I started I went from Vuse cigalikes to a EVOD clone with a variable voltage battery). While writing this, I am vaping 48 mg/ml and tonight is the first I've vaped since about May 28. I have to admit, the vape is a little harsh (throat hit wise), but I am, again, getting the alcohol+ euphoric rush!)

 

[NealBJr]

If you look back in this thread, I have done that. When I started about 8 months ago (I mean, at the end of the first 2 months), I was doing about 0.5 ml of 45-48 mg/ml juice. For the last several months of my most recent run I was doing about 1.0-1.6 ml. I understand that all of this is equipment dependent and that when one factors in dripping, all bets are off. However, the last paper that I found that did a serious analysis of blood chemistry used similar equipment to what i have been using (I'm currently using an EVOD-like SmokTech Glass cartomizer, and when I started I went from Vuse cigalikes to a EVOD clone with a variable voltage battery). While writing this, I am vaping 48 mg/ml and tonight is the first I've vaped since about May 28. I have to admit, the vape is a little harsh (throat hit wise), but I am, again, getting the alcohol+ euphoric rush!)

Yes, that is expected. If you're doing blood analysis, remember most nicotine related studies have been done with traditional tobacco. There are other chemicals involved that stimulate the effects of nicotine, and secondly, reduce the break down of nicotine in the blood. So most of the previous studies regarding nicotine aren't really conclusive when it comes to vaping.

Inhalation is of course the best nicotine delivery system. For a true study to be done, I would suggest mixtures containing a single base and nicotine, with no other additives for flavor. Studies that might lead to slightly different results, is a study with just nicotine and Vegetable Glycerine, and a study with nicotine and Propylene glycol and observe the effect. I would hypothesize that the difference might be slightly different, since the break down of those substances might affect the metabolism, and the break down of nicotine. It may not be much of a difference, but it's worth noting.

 

[mosspa]

Follow-up: I've been vaping for about 10 min (about 10 drags). I feel a bit light headed, but I'm not dizzy. Also, I feel that I'm more than ready to go to sleep.

 

[mosspa]

Yes, that is expected. If you're doing blood analysis, remember most nicotine related studies have been done with traditional tobacco. There are other chemicals involved that stimulate the effects of nicotine, and secondly, reduce the break down of nicotine in the blood. So most of the previous studies regarding nicotine aren't really conclusive when it comes to vaping.

Inhalation is of course the best nicotine delivery system. For a true study to be done, I would suggest mixtures containing a single base and nicotine, with no other additives for flavor. Studies that might lead to slightly different results, is a study with just nicotine and Vegetable Glycerine, and a study with nicotine and Propylene glycol and observe the effect. I would hypothesize that the difference might be slightly different, since the break down of those substances might affect the metabolism, and the break down of nicotine. It may not be much of a difference, but it's worth noting.

Yes, I agree. All of my experiences are based on a 75/25% PG/VG vehicle (which is about the only thing that has remained constant for all of my vaping experience since I moved from the Vuse product).

 

[mosspa]

Yes, that is expected. If you're doing blood analysis, remember most nicotine related studies have been done with traditional tobacco. There are other chemicals involved that stimulate the effects of nicotine, and secondly, reduce the break down of nicotine in the blood. So most of the previous studies regarding nicotine aren't really conclusive when it comes to vaping.

Inhalation is of course the best nicotine delivery system. For a true study to be done, I would suggest mixtures containing a single base and nicotine, with no other additives for flavor. Studies that might lead to slightly different results, is a study with just nicotine and Vegetable Glycerine, and a study with nicotine and Propylene glycol and observe the effect. I would hypothesize that the difference might be slightly different, since the break down of those substances might affect the metabolism, and the break down of nicotine. It may not be much of a difference, but it's worth noting.

I'm too lazy to go back and look, but the studies I cited concerned blood nicotine concentrations of vaped nicotine. I don't remember what the vehicle was, but I assume it was some ratio of PG/VG. I would think that few people vape with pure PG or VG, so the studies that use some combination would probably be most useful. Most medical inhalation devices use PG as the vehicle, and I assume there is a reason for this, since glycerol is cheaper to manufacture.

 

[DavidOck]

Most medical inhalation devices use PG as the vehicle, and I assume there is a reason for this, since glycerol is cheaper to manufacture.

Just a guess here, but I'd think the antiseptic qualities of PG might be the reason for it's use in inhalers...

 

[Alien Traveler]

Just a guess here, but I'd think the antiseptic qualities of PG might be the reason for it's use in inhalers...

Interesting question. Interesting enough that I went Googling. But no usable results on first two pages. It looks like now it is either not used or used in rather special devices, nebulizers. It looks like standard metered inhalers do not use PG at all.

 

[mosspa]

Just one thing to note... the nicotine content has nothing to do with nicotine intake. An evod setup running at 3.3V might deliver less nicotine than my Sigeli 100 @ 6mg/ml. Instead of the person saying he takes X amount of vapes of X amount of concentration, he should note how many milliliters of what dosage of ejuice has been vaped to get a more accurate measure. If he consumed 1ml of 48mg juice during those 100 vapes, then he's getting about a pack per day intake. If he consumed 10 ml of 48mg juice during those 100 vapes, then yes, he is doing some serious overdosing.

I did mention it. In late May when I quit for the summer, I was vaping a little more than 1.5 ml of 45 mg/ml juice per day. Still, you need to look at the paper I cited for an estimate of how that would compare to cigarettes.

 

[gerrymi]

It looks like now it is either not used or used in rather special devices, nebulizers.

THE BACTERICIDAL ACTION OF PROPYLENE GLYCOL VAPOR ON MICROORGANISMS SUSPENDED IN AIR. I

 

[Alien Traveler]

THE BACTERICIDAL ACTION OF PROPYLENE GLYCOL VAPOR ON MICROORGANISMS SUSPENDED IN AIR. I

What have an old paper from 1942 has to do with current use or not use of PG in asthma inhalers?

 

[DC2]

This is a good collection of information regarding vaping and propylene glycol...
National Vapers Club - Meeting Place for lovers of e-cigarettes, personal vaporizers and all things "fog" producing!

 

[gerrymi]

Nicotine is believed to be effective for treating conditions with attention deficits or memory issues, such as ADD/ADHD, Alzheimer's and schizophrenia. It is also thought to be effective for treating pain, depression and mild cognitive impairments. The key is to provide nicotine to the brain through modes other than through smoking.

Nicotine may be effective cognitive enhancer - National Weird News | Examiner.com

 

[mosspa]

Quick update. I've been reliably vaping about 45 mg/ml of nicotine at about 5.7W every day for the last three months. The semester is over Dec 11. I plan on taking a full 4 week hiatus from vaping starting on that date. This is my third nicotine-on cycle since starting this thread, and I'll report whether or not I got addicted this time. However, I am still seeing remarkable freedom of senior-moments during my lectures. So, it's still a go for me!

 

[Shirtbloke]

I'd be interested to hear how your migraine problems are coming on. Are they still diminished since vaping and do they come back when you stop?

 

[HyOnLyph]

mosspa, Thank you for continuing this post. It is most interesting.

 

[sofarsogood]

Quick update. I've been reliably vaping about 45 mg/ml of nicotine at about 5.7W every day for the last three months. The semester is over Dec 11. I plan on taking a full 4 week hiatus from vaping starting on that date. This is my third nicotine-on cycle since starting this thread, and I'll report whether or not I got addicted this time. However, I am still seeing remarkable freedom of senior-moments during my lectures. So, it's still a go for me!

My prediction is you won't have withdrawal symptoms. I haven't tried to quit but I'm starting to wonder about the degree of difficulty now that I haven't smoked for a year.

On another topic. You worked for the government. They are contemplating rules for release with weeks or a month or two that might restrict access to vaping hardware and/or e liquid. The biggest concern of vapers is whether nicotine for mixing at home might be impossible to get in the near future. Do you have any insight into the FDA's options relating to that? A 10 year supply of nic is absurdly cheap to buy and easy to store but I hate doing that if restrictions on that aren't on the FD roadmap.

 

[gerrymi]

from Rolling Stone:

It may come as a surprise to learn that nicotine, when removed from cigarettes, is relatively benign. A beguiling substance, nicotine operates as both an upper and a downer depending on the state of the user, proven to simultaneously sharpen focus and calm nerves. "In some ways I think of nicotine as the perfect psychotropic drug," says Paul Newhouse, a scientist at Vanderbilt University. He has spent his career administering nicotine to improve cognitive functioning in those suffering a variety of conditions, from Alzheimer's to Parkinson's to the mental fog created by chemotherapy and HIV medications. "The nicotinic receptors in the brain act as modulators rather than classic transmitters, scanning the system and stimulating what needs to be stimulated and relaxing what needs to be relaxed," Newhouse says, explaining both nicotine's therapeutic potential and appeal for recreational use. "That's why you have a smoker who uses a cigarette to wake up and to go to sleep."

E-Cigs' Inconvenient Truth: It's Much Safer to Vape

 

[mosspa]

Several things to report:

@Shirtbloke - Migraines are still under control.. Also, in regard to that eventuality, we start classes in about 10 days, and I have yet had a serious urge to vape for the last 2.5 weeks, however, I have been having more 'sinus' type headaches than I have had when I vape (and these aren't due to allergies or changing atmospheric conditions). Could be stress, though.

 

[mosspa]

I just read the Rolling Stone article linked by gerrymi. Just out of curiosity, has anybody here who has been vaping for a while started developed "popcorn cough"?

 

[Alien Traveler]

I just read the Rolling Stone article linked by gerrymi. Just out of curiosity, has anybody here who has been vaping for a while started developed "popcorn cough"?

I see you are a great fan of Dr. Skinner, you even borrowed his portrait as your avatar...