What they have in their favor is that, unlike Chantix, they are actually based on nicotine.
It may turn out to be a similar situation to Razadyne. First, there was a
supplement called galantamine which was a chemical extracted from the snow drop flower. It was discovered that this plant appeared to help aging folks maintain their cognitive abilities a little longer. Then a pharmaceutical company got hold of it, did clinical trials, and got it approved as a treatment for Alzheimer's Disease. FDA then attempted to force the
supplement off the market; but since it was sold prior to the approval of the pharma-form, they were unable to do so. It was "grandfathered" in as a
supplement. To my knowledge, the drug and the supplement versions are basically identical.
Article on the topic: Mary Ann Liebert, Inc. - Alternative and Complementary Therapies - 7(6):380
You can buy a month's supply of Galantamine supplement capsules for $40, or get a Rx for Razadyne and spend about $200 per month.
The question I have about the Targacept treatments is whether they will be taking the nicotine molecule and tweaking it in some fashion. If so, they might introduce problematic side effects that don't exist in the natural form.