As others have already stated. Go with your gut, and definitely discuss it with the doctor.
Just for something you can grab onto though so you aren't pulling your hair out ... I moved to Kansas City, MO for a little over a year - job relocation. I had just started vaping not long before this also.
About 4 months there and my ankles started to swell a bit.. then began to look 'bruised' is the only way I can describe it. They finally started to hurt as well. Nothing I did seemed to help. I finally became concerned and went to a nephrologist after a general physician could come up with nothing.
He found my levels to be slightly high. I told him about the vaping. Showed him my e-cig, told him how much I used it per day (and fudged on the HIGH side just in case)... I told him that it was the only thing I could think of that was different in the last few months besides moving up there.
Ends up - I'm a country boy. I am spoiled to fresh air and fresh well water. I moved into a high industrial area near the university I was working at, and my system balked in a nutshell. He told me I could get on an array of meds, cleansing diets, etc. - or go home.
I talked it over with the boss and they relocated me to Alabama - and I got a place out in the country. Problem resolved itself in about 3 weeks!!
Obviously - it sounds like your wife has other issues involved, but my point is that *I* was the one vaping... and I consider myself a pretty heavy vaper. Have been for some time now too. I don't think you are responsible for 'second hand vapor' kidney failure.
Basically, always err on the side of caution in situations like this sure, but please don't punish yourself on this. I honestly don't think you are to blame. At least wait until you guys have gone through the rounds with the doctors eh?
Take care and all the best to you and your wife!!
- Hap