Pfizer ended up paying huge fines under the False Claims Act and civil damages for common law fraud because it promoted unapproved uses of the drug which were not effective. The First Amendment is not a license to commit fraud.Guess that argument didn't work for Pfizer.
"The commercially successful marketing “miracle” of Nuerontin was achieved through a collaborative effort of the company and leading physicians who were given financial incentives to encourage their colleagues–under the pretext of providing “continuing medical education”–to prescribe a largely ineffective drug for unapproved, diverse and unrelated conditions. Essentially physicians were “educated” to use their prescribing license to increase profits rather than to improve their patients’ health. The Wall Street Journal reports that studies have found off-label use accounted for 40% to 50% of all prescriptions." LINK
Furthermore, the government can make a good argument that it has a substantial interest in prohibiting the marketing of prescription drugs for uses which have not been thoroughly tested for efficacy and safety.
ETA: Guess who ultimately ends up paying the huge fines and civil damages? Maybe we need to figure out a way to punish the individuals responsible for such things.
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