I completely agree. I think this is what Kurt meant by the importance of standardising puff protocols etc. - so that we get as close as possible to consistently replicating vaping across studies and use real time vapers in studies if possible. The big problem is that things move so fast that research tends to be behind the times.
Thats a big problem, and IMO overall impossible to solve.
The current "standard" puff protocol is a 3 second, 55ml puff every 30 seconds. This works ok for cigalikes and small tanks, which were popular ~3 years ago (think Evods or early ProTanks), but will not be able to simulate restricted or full lung hits at higher power. You´d need alot more volume for that, obviously.
Those old tanks had no airflow control and the usable Wattage range was very narrow, so a single puff profile, while not "perfect" for every device, will work decently.
Now think about about the many possibilities you have with even a simple random SubTank/Mod combo today.
Wattage range far wider. Close airflow halfway/a third or go fully open. How long and hard should the draw be?
Stuff like this cannot be standardised, and I am not even talking about different atties now. I think everybody agrees that using the same protocol on a Kanger SubTank and a Smok TFVsomething is not going to give "real life" results.