An example of a common false that is all over ECF.
It was explained to me that the mesh size depends on the PG/VG content of you juice.
(Rough ratios)
250-- 100-50/50 higher VG
325-- 70/30-60/40 PG/VG
400-- 100-80/20 higher PG
Proven scientifically:
Viscosty doesn't matter and 325 will not wick better than 400 or 500.
comparing oranges to oranges
PG will rise higher in a 400 mesh than on a 325 mesh.
Vg will rise higher in a 400 mesh than on a 325 mesh.
On the same 400 wick PG will rise higher than VG because of cohesion forces, but it will not rise higher on 325 than on 400,
All will rise higher and faster on #500
It was explained to me that the mesh size depends on the PG/VG content of you juice.
(Rough ratios)
250-- 100-50/50 higher VG
325-- 70/30-60/40 PG/VG
400-- 100-80/20 higher PG
Proven scientifically:
Viscosty doesn't matter and 325 will not wick better than 400 or 500.
comparing oranges to oranges
PG will rise higher in a 400 mesh than on a 325 mesh.
Vg will rise higher in a 400 mesh than on a 325 mesh.
On the same 400 wick PG will rise higher than VG because of cohesion forces, but it will not rise higher on 325 than on 400,
All will rise higher and faster on #500
But then I've been having nothing but wicking problems. 
being a perfectionist that he is
if these 2 questions have already been answered 
as for the fill holes -- I use the tips of toothpicks for mine & my brother uses small pieces of mesh for his, I take that for optimal wicking -- they'll have to go then