Almost any vape with nicotine will. My wife has never used nicotine in any form. Very early on, I had some Halo Belgian Cocoa at 18 mg in their eGo style setup with something like a 2.4 ohm coil and she remarked how great that smelled. So I asked her, "wanna try it?". She took one puff and her reaction was, "Whoa!" It was an almost instant buzz which she didn't care for at all.Lets face it, the Juuls give a non-smoker a buzz.